Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Clinical correlation of asbestos bodies in BAL fluid.

Authors: Vathesatogkit, Pratan; Harkin, Timothy J; Addrizzo-Harris, Doreen J; Bodkin, Marion; Crane, Michael; Rom, William N

Published In Chest, (2004 Sep)

Abstract: Asbestos bodies (AB) in BAL cells are specific markers of asbestos exposure.We retrospectively reviewed BAL cytocentrifuge slides of 30 utility workers with a history of asbestos exposure and 30 normal volunteers. BAL cytocentrifuge slides were blinded and scanned under 40 x light microscope.AB were found more frequently in subjects with a history of asbestos exposure compared to normal volunteers (10 of 30 subjects, 33%, vs 0 of 30 subjects). The mean number of AB seen in the AB-positive group was 2.7 per slide. Demographic data were comparable including age, gender, and smoking. Exposure histories were also similar: duration > 20 years, onset > 30 years ago, and time since last exposure > 7 years. More AB-positive patients reported respiratory symptoms (70% vs 26%, p < 0.05). High-resolution CT scans of AB-positive patients revealed a higher prevalence of parenchymal disease (70% vs 26%, p < 0.05). AB-positive subjects had reduced pulmonary function compared to AB-negative subjects: FVC (86% vs 97% predicted), FEV(1) (77% vs 92% predicted, p < 0.05), and diffusion capacity of the lung for carbon monoxide (76% vs 104% predicted, p < 0.01).In individuals with a history of asbestos exposure, the presence of AB in BAL cells is associated with higher prevalence of parenchymal abnormalities, respiratory symptoms, and reduced pulmonary function.

PubMed ID: 15364780 Exiting the NIEHS site

MeSH Terms: Asbestos/analysis*; Asbestosis/diagnosis*; Asbestosis/pathology; Bronchoalveolar Lavage Fluid/cytology*; Centrifugation; Female; Forced Expiratory Volume/physiology; Humans; Male; Middle Aged; Occupational Exposure/adverse effects; Pulmonary Diffusing Capacity/physiology; Risk Factors; Smoking/adverse effects; Tomography, Spiral Computed; Vital Capacity/physiology

to Top