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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: More than structural cells, fibroblasts create and orchestrate the tumor microenvironment.

Authors: Baglole, Carolyn J; Ray, Denise M; Bernstein, Steven H; Feldon, Steven E; Smith, Terry J; Sime, Patricia J; Phipps, Richard P

Published In Immunol Invest, (2006)

Abstract: The tumor microenvironment comprises many cell types including infiltrating immune cells such as lymphocytes, endothelial cells and a complex stroma consisting mainly of fibroblasts. Fibroblasts are heterogeneous and consist of Thy-1+ and Thy-1- subsets that define different biosynthetic and differentiation potential. They produce mediators linked to carcinogenesis and metastasis, including Cox-2 and PGE2, both of which are also increased in most cancers. This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses.

PubMed ID: 16916756 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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