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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Some comments on potency measures in mutagenicity research.

Authors: Margolin, B H; Kim, B S; Smith, M G; Fetterman, B A; Piegorsch, W W; Zeiger, E

Published In Environ Health Perspect, (1994 Jan)

Abstract: In this article, the measurement of the potency of a chemical or mixture from its dose response in a particular assay is addressed. Attention is focused on data from the Ames Salmonella assay. Three measures of potency are explored and shown to be highly correlated. The presentation then discusses specific areas of research that might benefit from a study of potency.

PubMed ID: 8187732 Exiting the NIEHS site

MeSH Terms: Dose-Response Relationship, Drug; Hazardous Substances/toxicity*; Mutagenicity Tests/statistics & numerical data; Salmonella/drug effects*

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