Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: DNA fingerprinting analysis of radiation-induced rat skin tumors.

Authors: Felber, M; Burns, F J; Garte, S J

Published In Cancer Biochem Biophys, (1994 Oct)

Abstract: DNA fingerprinting analysis was performed on rat skin tumors induced by high linear energy transfer neon ion radiation. Most of these tumors (13/15) showed DNA-fingerprint variability between independently isolated tumors from the same animal. These changes include multiple band shifts and extra bands. Comparisons of DNA fingerprints were also made on successive biopsy samples from the same tumor. Each of 3 neon-induced tumors and 2 of 8 electron (low LET) induced tumors showed progressive loss of amplified sequences, gain of amplified sequences, deletions, band shifts, and the appearance of extra bands in progressive biopsies. These results provide evidence for LET-specific effects on genomic instability in radiation-induced rat skin tumors.

PubMed ID: 7728737 Exiting the NIEHS site

MeSH Terms: Animals; Biopsy; Blotting, Southern; DNA Fingerprinting*; DNA, Neoplasm/analysis*; Male; Mutation; Neoplasms, Radiation-Induced/chemistry*; Neoplasms, Radiation-Induced/pathology; Rats; Rats, Sprague-Dawley; Skin Neoplasms/chemistry*; Skin Neoplasms/pathology

to Top