Title: Role of H-ras in the malignant progression of rat tracheal epithelial cells.
Authors: Cosma, G; Hubbard, F; Jamasbi, R J; Marchok, A; Garte, S J
Published In J Cancer Res Clin Oncol, (1994)
Abstract: The effect of an activated H-ras oncogene on the progression of neoplasia was studied in transformed rat tracheal epithelial cells. Nude mouse tumours produced by injection of these cells exhibited a higher fraction of cells containing the mutant ras gene that did the injected cells, while a subclone that lacked the ras mutation was much less tumorigenic than parental cells. Serial passage of one cell line containing a ras mutation resulted in an increase in the fraction of ras-mutated cells, which suggests that, in this line, ras activation may confer a selective advantage in vitro as well. However, this was not seen in another ras-containing line, suggesting the importance of alternative pathways in malignant progression of rat tracheal epithelial cells.
PubMed ID: 7962039
MeSH Terms: Animals; Cell Transformation, Neoplastic/genetics*; Epithelium/physiology; Gene Expression Regulation, Neoplastic; Genes, ras/physiology*; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Rats; Rats, Inbred F344; Trachea/physiology*; Tracheal Neoplasms/genetics*; Tumor Cells, Cultured