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Publication Detail

Title: Induction of arsenite tolerance and thermotolerance by arsenite occur by different mechanisms.

Authors: Wang, Z; Hou, G; Rossman, T G

Published In Environ Health Perspect, (1994 Sep)

Abstract: Both V79 and As/R28A cells (an arsenite-resistant Chinese hamster V79 cell variant) show increased resistance to toxic concentrations of arsenite after pretreatment with a nontoxic concentration. The induced tolerance can be completely inhibited by actinomycin D or cycloheximide. Pretreatment with a nontoxic heat shock (45 degrees C, 10 min) resulted in a clear increased thermotolerance in both cell lines but failed to induce arsenite tolerance in either cell line. Pretreatment with arsenite induced a thermotolerance in V79 cells but not in As/R28A cells. These results are consistent with a model whereby the signal for induction of arsenite tolerance involves binding of arsenite to a protein effector which is amplified in the As/R28A line, thereby preventing action of arsenite in the regulation of heat shock factor which induces the heat shock response.

PubMed ID: 7843143 Exiting the NIEHS site

MeSH Terms: Animals; Arsenites/pharmacology*; Cell Line; Cycloheximide/pharmacology; Dactinomycin/pharmacology; Drug Resistance; Drug Tolerance; Hot Temperature*; Protein Biosynthesis; RNA, Messenger/biosynthesis; Sodium Compounds/pharmacology*

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