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Publication Detail

Title: Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal.

Authors: Donnelly, C; Leisenring, W; Kanki, P; Awerbuch, T; Sandberg, S

Published In Bull Math Biol, (1993)

Abstract: To explore the biological similarities and differences between the HIV-1 and HIV-2 viruses, we model the probability of male-to-female transmission of either HIV virus as a function of the number of sexual partners, the prevalence of the viruses and the infectivity per contact. Using maximum likelihood estimation theory and data from a prospective study of registered female prostitutes in Dakar, Senegal, we estimate and compare the infectivities of HIV-1 and HIV-2. Graphical goodness-of-fit methods are used to show that our model fits the data well. We find that in male-to-female transmission HIV-1 is significantly more infectious than HIV-2. This finding is consistent with other data from laboratory and epidemiologic studies comparing the biology of HIV-1 and HIV-2.

PubMed ID: 8318928 Exiting the NIEHS site

MeSH Terms: Acquired Immunodeficiency Syndrome/epidemiology; Acquired Immunodeficiency Syndrome/transmission*; Cohort Studies; Female; HIV-1*; HIV-2*; Humans; Male; Mathematics; Models, Statistical; Prevalence; Probability; Prospective Studies; Senegal/epidemiology; Sex Work*

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