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Publication Detail

Title: 5-Hydroxytryptophan (5-HTP) augments spontaneous and evoked phrenic motoneuron discharge in spinalized rats.

Authors: Mitchell, G S; Sloan, H E; Jiang, C; Miletic, V; Hayashi, F; Lipski, J

Published In Neurosci Lett, (1992 Jul 06)

Abstract: Experiments on anesthetized, spinalized rats were conducted to determine the effects of systemic 5-hydroxytryptophan (5-HTP) administration on: (1) spontaneous phrenic nerve activity and (2) evoked phrenic responses to short latency, non-serotonergic synaptic inputs elicited by electrical stimulation of lateral funiculus. 5-HTP augmented spontaneous phrenic activity and allowed expression of a second, longer latency evoked response. Both effects were antagonized by methysergide. Our results suggest that spinal serotonin increases the efficacy of synaptic inputs to phrenic motoneurons.

PubMed ID: 1508404 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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