Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Expression of human paraoxonase (PON1) during development.

Authors: Cole, Toby B; Jampsa, Rachel L; Walter, Betsy J; Arndt, Tara L; Richter, Rebecca J; Shih, Diana M; Tward, Aaron; Lusis, Aldons J; Jack, Rhona M; Costa, Lucio G; Furlong, Clement E

Published In Pharmacogenetics, (2003 Jun)

Abstract: Paraoxonase (PON1), a HDL-associated enzyme, protects against toxicity from specific organophosphorus compounds and oxidized lipids. Common polymorphisms in the PON1 gene have been identified and characterized in the coding region, 5' regulatory region and 3' UTR. The Q192R coding region polymorphism determines substrate-dependent differences in catalytic efficiency of hydrolysis. The -108CT polymorphism in the 5' regulatory region has a significant effect on PON1 expression, with the -108C allele expressing on average twice the level of plasma PON1 as the -108T allele. In addition to the effects of regulatory and coding region polymorphisms on PON1 levels and activity, plasma PON1 levels are also developmentally regulated. Since PON1 levels are important in determining resistance to specific organophosphorus compounds, the time course of appearance of PON1 in newborns is of great interest.We report here that PON1 levels plateau between 6 to 15 months of age, and that variability in the age at which PON1 levels plateau is quite variable among individuals. In mice and rats, plasma PON1 activity reaches a plateau at 3 weeks of age. In mice that lack endogenous PON1, human transgenes encoding either PON1(Q192) or PON1(R192) under the control of the human PON1 regulatory sequences exhibited a similar time course of expression as that seen in wild-type mice, indicating conservation of the developmental regulatory elements between mouse and human PON1.

PubMed ID: 12777966 Exiting the NIEHS site

MeSH Terms: Animals; Aryldialkylphosphatase/blood; Aryldialkylphosphatase/genetics*; Child, Preschool; Gene Expression Regulation, Developmental*; Gene Expression Regulation, Enzymologic*; Humans; Infant; Infant, Newborn; Mice; Mice, Transgenic

Back
to Top