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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.

Authors: Guengerich, F P; Shimada, T; Raney, K D; Yun, C H; Meyer, D J; Ketterer, B; Harris, T M; Groopman, J D; Kadlubar, F F

Published In Environ Health Perspect, (1992 Nov)

Abstract: A number of different approaches have been used to determine the catalytic selectivity of individual human enzymes toward procarcinogens. Studies with cytochrome P450 (P450) enzymes and glutathione S-transferases are summarized here, and recent work with pyrrolizidine alkaloids, aflatoxins, 4,4'-methylenebis(2-chloroaniline), and ethyl carbamate is discussed. In some cases a single enzyme can catalyze both activation and detoxication reactions of a chemical. The purification and characterization of human lung P4501A1 and the development of a noninvasive assay for human P4502E1 are also described.

PubMed ID: 1486866 Exiting the NIEHS site

MeSH Terms: Aflatoxin B1/metabolism; Biological Assay; Carcinogens/metabolism*; Catalysis; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System/metabolism*; Glutathione Transferase/metabolism*; Humans; Methylenebis(chloroaniline)/metabolism; Oxidation-Reduction; Oxidoreductases, N-Demethylating/metabolism; Pyrrolizidine Alkaloids/metabolism; Urethane/metabolism

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