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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Human somatic mutation assays as biomarkers of carcinogenesis.

Authors: Compton, P J; Hooper, K; Smith, M T

Published In Environ Health Perspect, (1991 Aug)

Abstract: This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed.

PubMed ID: 1954924 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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