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Publication Detail

Title: Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicity.

Authors: Gavin, C E; Gunter, K K; Gunter, T E

Published In Biochem J, (1990 Mar 01)

Abstract: Manganese shares the uniport mechanism of mitochondrial calcium influx, accumulates in mitochondria and is cleared only very slowly from brain. Using dual-label isotope techniques, we have investigated both Mn2+ and Ca2+ mitochondrial efflux kinetics. We report that (1) there is no significant Na(+)-dependent Mn2+ efflux from brain mitochondria; (2) Mn2+ inhibits both Na(+)-dependent and Na(+)-independent Ca2+ efflux in brain, in a mode that appears to be primarily competitive and with apparent Ki values of 5.1 and 7.9 nmol/mg respectively; and (3) Ca2+ does not appear to inhibit Mn2+ efflux from brain mitochondria. Findings (1) and (2) suggest the possibility of mitochondrial accumulation of both Mn2+ and Ca2+ in Mn2(+)-intoxicated brain.

PubMed ID: 2317189 Exiting the NIEHS site

MeSH Terms: Animals; Biological Transport/drug effects; Brain/metabolism*; Calcium/metabolism*; Female; In Vitro Techniques; Intracellular Membranes/metabolism; Kinetics; Manganese Poisoning; Manganese/pharmacology*; Mitochondria/metabolism*; Rats; Rats, Inbred Strains; Sodium/pharmacology

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