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National Institute of Environmental Health Sciences

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Publication Detail

Title: Sample size determination for pair-matched case-control studies where the goal is interval estimation of the odds ratio.

Authors: Satten, G A; Kupper, L L

Published In J Clin Epidemiol, (1990)

Abstract: Samples sizes are calculated for case-control studies where 1:1 matching has been employed, and where the goal is the interval estimation of the odds ratio. The optimal sample size is defined to be the smallest value for which a 100(1 - alpha)% confidence interval for the log odds ratio will not exceed a specified width 2 delta with specified probability (1 - gamma). This approach is similar in spirit to the power-based approach for sample size determination when significance testing is the goal. Tables of sample sizes are presented for various choices of parameters. We also find considerable disagreement with a published method based on expected numbers of discordant pairs.

PubMed ID: 2319281 Exiting the NIEHS site

MeSH Terms: Case-Control Studies*; Humans; Statistics as Topic

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