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National Institute of Environmental Health Sciences

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Publication Detail

Title: The in vitro biotransformation of 2-aminofluorene in the visceral mass of the Pacific oyster, Crassostrea gigas.

Authors: Schlenk, D; Buhler, D R

Published In Xenobiotica, (1990 Jun)

Abstract: 1. The in vitro biotransformation of 2-aminofluorene (2-AF) was examined in visceral mass microsomes from the Pacific oyster Crassostrea gigas. 2. The major metabolite was N-formyl-2-aminofluorene with smaller quantities of N-hydroxy-2-aminofluorene and nitroso-2-aminofluorene or 2-nitrofluorene. 3. The mechanism of N-oxidation was explored using various inhibitors, stimulators, cofactors, and pH modifications within incubations. 4. N-Oxidation may occur via a one electron mechanism which involves a transition metal and/or lipid peroxidation. 5. Flavin-containing monooxygenase and possibly prostaglandin synthase also seem to play a role in N-oxidation.

PubMed ID: 2120855 Exiting the NIEHS site

MeSH Terms: Animals; Biotransformation; Catalase/pharmacology; Edetic Acid/pharmacology; Fluorenes/metabolism; Fluorenes/pharmacokinetics*; Glutathione/pharmacology; Hydrogen-Ion Concentration; Microsomes/drug effects; Microsomes/metabolism; NADP/pharmacology; Ostreidae/metabolism*; Oxidation-Reduction; Superoxide Dismutase/pharmacology

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