Title: L-arginine is a precursor for nitrate biosynthesis in humans.
Authors: Leaf, C D; Wishnok, J S; Tannenbaum, S R
Published In Biochem Biophys Res Commun, (1989 Sep 15)
Abstract: Nitrogen from L-arginine was incorporated into urinary nitrate in human subjects. Two subjects given an oral dose of [15N2]L-arginine excreted 24 and 17 umol [15N]nitrate/24 hr, respectively, in their urine in the 24 hr period following the dose. This work demonstrates that L-arginine, a nitrogen source for biosynthesized nitrate in cultured cells and research animals, is a precursor for endogenously synthesized nitrate in humans.
PubMed ID: 2783109
MeSH Terms: Arginine/metabolism*; Chemical Phenomena; Chemistry; Female; Humans; Male; Nitrates/metabolism*; Nitrates/urine