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Publication Detail

Title: Glucocorticoids potentiate kainic acid-induced seizures and wet dog shakes.

Authors: Lee, P H; Grimes, L; Hong, J S

Published In Brain Res, (1989 Feb 20)

Abstract: Glucocorticoid effects on kainic acid-induced motor seizures and wet dog shakes in rats were investigated by adrenalectomy and dexamethasone treatment. One-day adrenalectomy attenuated kainic acid-induced wet dog shakes and seizure activity. These effects were restored by dexamethasone. Administration of dexamethasone to non-adrenalectomized rats potentiated kainic acid-induced wet dog shakes and severity of seizure activity. These results suggest that glucocorticoids may play an important role in modulating the severity of kainic acid-induced seizures and wet dog shakes.

PubMed ID: 2713658 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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