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Who We Fund: Publications associated with Basic Cellular And Molecular Research - Metabolism

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 143 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
A rapid and simple fluorescence enzyme-linked immunosorbent assay for tetrabromobisphenol A in soil ...   Fu, Hui-Jun; Wang, Yu; Xiao, Zhi-Li; Wang, Hong; Li, Zhen-Feng; Shen, Yu-Dong; Lei, Hong-Tao; ... P42ES004699, R35ES030443 Ecotoxicol Environ Saf (2020 Jan 30) 31704326 Exiting the NIEHS site 2020 
An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors o ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Bioorg Med Chem (2020 Mar 15) 32044230 Exiting the NIEHS site 2020 
Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach.   Stefanovski, Darko; Shih, Pei-An Betty; Hammock, Bruce D; Watanabe, Richard M; Youn, Jang H P42ES004699, R35ES030443 Prostaglandins Other Lipid Mediat (2020 Jun) 31931080 Exiting the NIEHS site 2020 
Atropselective Disposition of 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) and Identification of Its Met ...   Wu, Xianai; Zhai, Guangshu; Schnoor, Jerald L; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R21ES027169 Chem Res Toxicol (2020 Jun 15) 31403789 Exiting the NIEHS site 2020 
Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine ...   Pressly, Brandon; Vasylieva, Natalia; Barnych, Bogdan; Singh, Vikrant; Singh, Latika; Bruun, D ... R35ES030443 Arch Toxicol (2020 Jun) 32239239 Exiting the NIEHS site 2020 
Development of potent inhibitors of the human microsomal epoxide hydrolase.   Barnych, Bogdan; Singh, Nalin; Negrel, Sophie; Zhang, Yue; Magis, Damien; Roux, Capucine; Hua, ... P42ES004699, R35ES030443 Eur J Med Chem (2020 May 01) 32203787 Exiting the NIEHS site 2020 
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.   Heintz, Melissa M; McRee, Rebecca; Kumar, Ramiya; Baldwin, William S R15ES017321, R15ES017321 PLoS One (2020) 32155178 Exiting the NIEHS site 2020 
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hy ...   Burmistrov, Vladimir; Morisseau, Christophe; D'yachenko, Vladimir; Karlov, Dmitry; Butov, Genna ... P42ES004699, R35ES030443 Bioorg Med Chem Lett (2020 02 01) 31870649 Exiting the NIEHS site 2020 
Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major ps ...   Zhang, Jiancheng; Tan, Yunfei; Chang, Lijia; Hammock, Bruce D; Hashimoto, Kenji P42ES004699, R35ES030443 J Affect Disord (2020 Jun 01) 32339103 Exiting the NIEHS site 2020 
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?   Panigrahy, Dipak; Gilligan, Molly M; Huang, Sui; Gartung, Allison; Cortés-Puch, Irene; Sime, P ... P42ES004699, R35ES030443 Cancer Metastasis Rev (2020 06) 32385712 Exiting the NIEHS site 2020 
Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression ...   Pu, Yaoyu; Yang, Jun; Chang, Lijia; Qu, Youge; Wang, Siming; Zhang, Kai; Xiong, Zhongwei; Zha ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2020 05 26) 32398374 Exiting the NIEHS site 2020 
Production of a specific monoclonal antibody for 1-naphthol based on novel hapten strategy and devel ...   Chen, Zi-Jian; Liu, Xi-Xia; Xiao, Zhi-Li; Fu, Hui-Jun; Huang, Yu-Ping; Huang, Shu-Yi; Shen, Y ... P42ES004699, R35ES030443 Ecotoxicol Environ Saf (2020 Jun 15) 32247241 Exiting the NIEHS site 2020 
Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials ...   Sun, Cheng-Peng; Zhang, Juan; Zhao, Wen-Yu; Yi, Jing; Yan, Jian-Kun; Wang, Ya-Li; Morisseau, ... P42ES004699, R35ES030443 Bioorg Chem (2020 Mar) 32032849 Exiting the NIEHS site 2020 
Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis mode ...   Trindade-da-Silva, Carlos A; Clemente-Napimoga, Juliana T; Abdalla, Henrique B; Rosa, Sergio Mar ... P42ES004699, R35ES030443 FASEB J (2020 May 13) 32400048 Exiting the NIEHS site 2020 
Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfuncti ...   Wang, Yuxin; Yang, Jun; Wang, Weicang; Sanidad, Katherine Z; Cinelli, Maris A; Wan, Debin; Hwa ... P42ES004699, R00ES024806, R35ES030443 Proc Natl Acad Sci U S A (2020 04 14) 32220957 Exiting the NIEHS site 2020 
1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor o ...   Liang, Zhibin; Zhang, Bei; Xu, Meng; Morisseau, Christophe; Hwang, Sung Hee; Hammock, Bruce D; ... P42ES004699, R35ES030443 ACS Chem Neurosci (2019 09 18) 31378059 Exiting the NIEHS site 2019 
2,3-Dichloro-3',4'-dihydroxybiphenyl.   Dhakal, Ram; Parkin, Sean; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R21ES027169 IUCrdata (2019 May) 32030359 Exiting the NIEHS site 2019 
3,5-Dichloro-3',4'-dimethoxybiphenyl.   Dhakal, Ram; Parkin, Sean; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R21ES027169 IUCrdata (2019 Apr) 32030358 Exiting the NIEHS site 2019 
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epile ...   Shen, Yijun; Peng, Weifeng; Chen, Qinglan; Hammock, Bruce D; Liu, Junyan; Li, Dongyang; Yang, ... P42ES004699, R35ES030443 Brain Behav Immun (2019 10) 31306773 Exiting the NIEHS site 2019 
Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts f ...   Suter, Melissa A; Aagaard, Kjersti M; Coarfa, Cristian; Robertson, Matthew; Zhou, Guodong; Jack ... P42ES007373, R01ES029382 Biochem Biophys Res Commun (2019 08 20) 31208719 Exiting the NIEHS site 2019 
Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced N ...   Rooney, John P; Oshida, Keiyu; Kumar, Ramiya; Baldwin, William S; Corton, J Christopher R15ES017321, R15ES017321 Toxicol Sci (2019 01 01) 30203046 Exiting the NIEHS site 2019 
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.   Chuo, Shih-Wei; Liou, Shu-Hao; Wang, Lee-Ping; Britt, R David; Poulos, Thomas L; Sevrioukova, ... R01ES025767 Biochemistry (2019 09 17) 31456404 Exiting the NIEHS site 2019 
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.   Heintz, Melissa M; Kumar, Ramiya; Rutledge, Meredith M; Baldwin, William S R15ES017321, R15ES017321 J Nutr Biochem (2019 08) 31202118 Exiting the NIEHS site 2019 
Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways.   Lee, Kin Sing Stephen; Yang, Jun; Niu, Jun; Ng, Connie J; Wagner, Karen M; Dong, Hua; Kodani, ... R35ES030443 ACS Cent Sci (2019 Sep 25) 31572788 Exiting the NIEHS site 2019 
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.   Dileepan, Mythili; Rastle-Simpson, Stephanie; Greenberg, Yana; Wijesinghe, Dayanjan S; Kumar, N ... R35ES030443 Front Pharmacol (2019) 31611798 Exiting the NIEHS site 2019 
Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic ac ...   Rand, Amy A; Rajamani, Anita; Kodani, Sean D; Harris, Todd R; Schlatt, Lukas; Barnych, Bodgan; ... P42ES004699, R35ES030443 J Lipid Res (2019 12) 31641036 Exiting the NIEHS site 2019 
Human CYP2A6, CYP2B6, AND CYP2E1 Atropselectively Metabolize Polychlorinated Biphenyls to Hydroxylat ...   Uwimana, Eric; Ruiz, Patricia; Li, Xueshu; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R21ES027169 Environ Sci Technol (2019 02 19) 30576102 Exiting the NIEHS site 2019 
Human DNA polymerase η has reverse transcriptase activity in cellular environments.   Su, Yan; Ghodke, Pratibha P; Egli, Martin; Li, Lin; Wang, Yinsheng; Guengerich, F Peter R01ES010546, R01ES025121, R01ES026955 J Biol Chem (2019 04 12) 30842261 Exiting the NIEHS site 2019 
Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules.   Sevrioukova, Irina R01ES025767 Biochemistry (2019 02 19) 30676743 Exiting the NIEHS site 2019 
Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and earl ...   Hassanin, A A I; Tavera-Garcia, M; Moorthy, B; Zhou, G D; Ramos, K S R01ES029382 Am J Physiol Lung Cell Mol Physiol (2019 12 01) 31596105 Exiting the NIEHS site 2019 
Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine.   Luo, Lin; Wei, Xiao-Qun; Jia, Bao-Zhu; Yang, Jin-Yi; Shen, Yu-Dong; Hammock, Bruce; Dong, Jie ... P42ES004699, R35ES030443 Biomolecules (2019 10 11) 31614550 Exiting the NIEHS site 2019 
Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Ste ...   Baldwin, William S R15ES017321, R15ES017321 Nucl Receptor Res (2019) 31815118 Exiting the NIEHS site 2019 
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deox ...   Chen, Yu-Jie; Zhang, Jian; Zhu, Ping-Ping; Tan, Xian-Wen; Lin, Qiu-Hong; Wang, Wen-Xia; Yin, ... R01ES025767 Drug Metab Dispos (2019 06) 30918015 Exiting the NIEHS site 2019 
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2019 Aug 30) 31480231 Exiting the NIEHS site 2019 
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group St ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Biochemistry (2019 04 16) 30912932 Exiting the NIEHS site 2019 
Synthesis and Characterization of Site-Specific O6 -Alkylguanine DNA-Alkyl Transferase-Oligonucleoti ...   Ghodke, Pratibha P; Albertolle, Matthew E; Johnson, Kevin M; Guengerich, F Peter R01ES010546, R01ES026955 Curr Protoc Nucleic Acid Chem (2019 03) 30657645 Exiting the NIEHS site 2019 
The abundant DNA adduct N7-methyl deoxyguanosine contributes to miscoding during replication by huma ...   Njuma, Olive J; Su, Yan; Guengerich, F Peter R01ES010546, T32ES007028 J Biol Chem (2019 06 28) 31101656 Exiting the NIEHS site 2019 
Toxicokinetics of Chiral PCB 136 and Its Hydroxylated Metabolites in Mice with a Liver-Specific Dele ...   Li, Xueshu; Wu, Xianai; Kelly, Kevin M; Veng-Pedersen, Peter; Lehmler, Hans-Joachim P30ES005605, P30ES006694, P42ES013661, R21ES027169 Chem Res Toxicol (2019 04 15) 30729780 Exiting the NIEHS site 2019 
Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome ...   Taneja, Guncha; Maity, Suman; Jiang, Weiwu; Moorthy, Bhagavatula; Coarfa, Cristian; Ghose, Rom ... R01ES029382 Sci Rep (2019 04 30) 31040347 Exiting the NIEHS site 2019 
Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese.   Damiri, Basma; Baldwin, William S R15ES017321, R15ES017321 Lipids (2018 09) 30421529 Exiting the NIEHS site 2018 
Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids.   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Tetrahedron Lett (2018 Mar 21) 30140110 Exiting the NIEHS site 2018 
High fat diet induced obesity is mitigated in Cyp3a-null female mice.   Kumar, Ramiya; Litoff, Elizabeth J; Boswell, W Tyler; Baldwin, William S R15ES017321, R15ES017321 Chem Biol Interact (2018 Jun 01) 29738703 Exiting the NIEHS site 2018 
Human Liver Microsomes Atropselectively Metabolize 2,2',3,4',6-Pentachlorobiphenyl (PCB 91) to a 1,2 ...   Uwimana, Eric; Li, Xueshu; Lehmler, Hans-Joachim P30ES005605, P42ES013661, R21ES027169 Environ Sci Technol (2018 05 15) 29659268 Exiting the NIEHS site 2018 
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum.   Liu, Yanna; Richardson, Evan S; Derocher, Andrew E; Lunn, Nicholas J; Lehmler, Hans-Joachim; Li ... P30ES005605, P30ES007033, P42ES013661, R21ES027169 Angew Chem Int Ed Engl (2018 12 10) 30376612 Exiting the NIEHS site 2018 
Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Mol Pharm (2018 01 02) 29232137 Exiting the NIEHS site 2018 
Non-Mammalian Nuclear Receptors: From Evolution to Human Disease.   Gissendanner, Chris R; Baldwin, William S; Schaaf, Marcel J M R15ES017321, R15ES017321 Nucl Receptor Res (2018) 30221173 Exiting the NIEHS site 2018 
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling ...   Polic, Vanja; Sevrioukova, Irina F; Auclair, Karine R01ES025767 Arch Biochem Biophys (2018 09 01) 29958895 Exiting the NIEHS site 2018 
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus.   Baldwin, William S; Boswell, W Tyler; Ginjupalli, Gautam; Litoff, Elizabeth J R15ES017321, R15ES017321 Nucl Receptor Res (2017) 28804711 Exiting the NIEHS site 2017 
Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-n ...   Kumar, Ramiya; Mota, Linda C; Litoff, Elizabeth J; Rooney, John P; Boswell, W Tyler; Courter, ... R15ES017321, R15ES017321 PLoS One (2017) 28350814 Exiting the NIEHS site 2017 
Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin al ...   Sengupta, Namrata; Reardon, Delaney C; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 PLoS One (2017) 28542405 Exiting the NIEHS site 2017 
Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Tr ...   Sedgeman, Carl A; Su, Yan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2017 05 15) 28395138 Exiting the NIEHS site 2017 
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.   Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd ... P30ES013508, R01ES025767 Cell Chem Biol (2017 Oct 19) 28919040 Exiting the NIEHS site 2017 
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.   Sevrioukova, Irina F R01ES025767 Biochemistry (2017 06 20) 28590129 Exiting the NIEHS site 2017 
Human DNA polymerase η accommodates RNA for strand extension.   Su, Yan; Egli, Martin; Guengerich, F Peter R01ES010546, R01ES026955 J Biol Chem (2017 11 03) 28972162 Exiting the NIEHS site 2017 
RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and th ...   Schmidt, Allison M; Sengupta, Namrata; Saski, Christopher A; Noorai, Rooksana E; Baldwin, Willi ... R15ES017321, R15ES017321 Chemosphere (2017 Dec) 28968576 Exiting the NIEHS site 2017 
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.   Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Proc Natl Acad Sci U S A (2017 01 17) 28031486 Exiting the NIEHS site 2017 
Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Sy ...   Wickramaratne, Susith; Ji, Shaofei; Mukherjee, Shivam; Su, Yan; Pence, Matthew G; Lior-Hoffmann ... R01ES010546, R01ES023350, R01ES025987 J Biol Chem (2016 Nov 04) 27621316 Exiting the NIEHS site 2016 
Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of H ...   Yeom, Mina; Kim, In-Hyeok; Kim, Jae-Kwon; Kang, KyeongJin; Eoff, Robert L; Guengerich, F Peter ... R01ES010546 Chem Res Toxicol (2016 Mar 21) 26914252 Exiting the NIEHS site 2016 
Kinetic analysis of bypass of 7,8-dihydro-8-oxo-2'-deoxyguanosine by the catalytic core of yeast DNA ...   Xue, Qizhen; Zhong, Mengyu; Liu, Binyan; Tang, Yong; Wei, Zeliang; Guengerich, F Peter; Zhang, ... R01ES010546 Biochimie (2016 Feb) 26700143 Exiting the NIEHS site 2016 
Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.   Choi, Jeong-Yun; Patra, Amritaj; Yeom, Mina; Lee, Young-Sam; Zhang, Qianqian; Egli, Martin; Gu ... R01ES010546 J Biol Chem (2016 Sep 30) 27555320 Exiting the NIEHS site 2016 
Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η.   O'Flaherty, D K; Patra, A; Su, Y; Guengerich, F P; Egli, M; Wilds, C J R01ES010546 Chem Sci (2016 Aug 01) 27574558 Exiting the NIEHS site 2016 
Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η.   Su, Yan; Egli, Martin; Guengerich, F Peter R01ES010546 J Biol Chem (2016 Feb 19) 26740629 Exiting the NIEHS site 2016 
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Huma ...   Patra, Amitraj; Zhang, Qianqian; Guengerich, F Peter; Egli, Martin R01ES010546 J Biol Chem (2016 Nov 11) 27694439 Exiting the NIEHS site 2016 
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.   Liu, Binyan; Xue, Qizhen; Tang, Yong; Cao, Jia; Guengerich, F Peter; Zhang, Huidong R01ES010546 Mutat Res Rev Mutat Res (2016 Apr-Jun) 27234563 Exiting the NIEHS site 2016 
Metals in Biology 2016: Molecular Basis of Selection of Metals by Enzymes.   Guengerich, F Peter R01ES010546 J Biol Chem (2016 Sep 30) 27462079 Exiting the NIEHS site 2016 
Perturbations in polar lipids, starvation survival and reproduction following exposure to unsaturate ...   Sengupta, Namrata; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2016 Feb) 26606184 Exiting the NIEHS site 2016 
Pre-Steady-State Kinetic Analysis of Single-Nucleotide Incorporation by DNA Polymerases.   Su, Yan; Peter Guengerich, F R01ES010546 Curr Protoc Nucleic Acid Chem (2016 06 01) 27248785 Exiting the NIEHS site 2016 
Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.   Kim, Jae-Kwon; Yeom, Mina; Hong, Jin-Kyung; Song, Insil; Lee, Young-Sam; Guengerich, F Peter; ... R01ES010546 Chem Res Toxicol (2016 10 17) 27603496 Exiting the NIEHS site 2016 
Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Hu ...   Patra, Amritraj; Su, Yan; Zhang, Qianqian; Johnson, Kevin M; Guengerich, F Peter; Egli, Martin R01ES010546 J Biol Chem (2016 Jul 01) 27226627 Exiting the NIEHS site 2016 
Arachidonic acid enhances reproduction in Daphnia magna and mitigates changes in sex ratios induced ...   Ginjupalli, Gautam K; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 Environ Toxicol Chem (2015 Mar) 25393616 Exiting the NIEHS site 2015 
Carcinogenesis of urethane: simulation versus experiment.   Lajovic, Andrej; Nagy, Leslie D; Guengerich, F Peter; Bren, Urban R01ES010546 Chem Res Toxicol (2015 Apr 20) 25642734 Exiting the NIEHS site 2015 
Characterization of thioether-linked protein adducts of DNA using a Raney-Ni-mediated desulfurizatio ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Curr Protoc Nucleic Acid Chem (2015 Mar 09) 25754888 Exiting the NIEHS site 2015 
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins.   Zdżalik, Daria; Domańska, Anna; Prorok, Paulina; Kosicki, Konrad; van den Born, Erwin; Falnes, ... R01ES010546 DNA Repair (Amst) (2015 Jun) 25797601 Exiting the NIEHS site 2015 
Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in ...   Chang, Shiou-chi; Fedeles, Bogdan I; Wu, Jie; Delaney, James C; Li, Deyu; Zhao, Linlin; Christ ... P30ES002109, R01ES010546, T32ES007020 Nucleic Acids Res (2015 Jun 23) 25837992 Exiting the NIEHS site 2015 
Repression of multiple CYP2D genes in mouse primary hepatocytes with a single siRNA construct.   Elraghy, Omaima; Baldwin, William S R15ES017321, R15ES017321 In Vitro Cell Dev Biol Anim (2015 Jan) 25124873 Exiting the NIEHS site 2015 
Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic ...   Rendic, Slobodan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2015 Jan 20) 25485457 Exiting the NIEHS site 2015 
The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA.   Sengupta, Namrata; Litoff, Elizabeth J; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2015 Jun) 25747156 Exiting the NIEHS site 2015 
Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex.   Litoff, Elizabeth J; Garriott, Travis E; Ginjupalli, Gautam K; Butler, LaToya; Gay, Claudy; Sco ... R15ES017321, R15ES017321 Gene (2014 Nov 15) 25239664 Exiting the NIEHS site 2014 
Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thali ...   Chowdhury, Goutam; Shibata, Norio; Yamazaki, Hiroshi; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2014 Jan 21) 24350712 Exiting the NIEHS site 2014 
The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia s ...   Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Gen Comp Endocrinol (2014 Sep 15) 25092536 Exiting the NIEHS site 2014 
Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylgu ...   Chowdhury, Goutam; Cho, Sung-Hee; Pegg, Anthony E; Guengerich, F Peter R01ES010546 Angew Chem Int Ed Engl (2013 Dec 2) 24130045 Exiting the NIEHS site 2013 
In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutage ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2013 Nov 18) 24191644 Exiting the NIEHS site 2013 
Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydrox ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2013 Jun 17) 23701509 Exiting the NIEHS site 2013 
Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine.   Maddukuri, Leena; Shuck, Sarah C; Eoff, Robert L; Zhao, Linlin; Rizzo, Carmelo J; Guengerich, ... R01ES010546, T32ES007028 Biochemistry (2013 Dec 3) 24171480 Exiting the NIEHS site 2013 
The time- and age-dependent effects of the juvenile hormone analog pesticide, pyriproxyfen on Daphni ...   Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2013 Aug) 23714148 Exiting the NIEHS site 2013 
Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.   Zhao, Linlin; Pence, Matthew G; Christov, Plamen P; Wawrzak, Zdzislaw; Choi, Jeong-Yun; Rizzo, ... R01ES010546, T32ES007028 J Biol Chem (2012 Oct 12) 22910910 Exiting the NIEHS site 2012 
Conjugation of butadiene diepoxide with glutathione yields DNA adducts in vitro and in vivo.   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Mar 19) 22181695 Exiting the NIEHS site 2012 
Contributions of human enzymes in carcinogen metabolism.   Rendic, Slobodan; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Jul 16) 22531028 Exiting the NIEHS site 2012 
Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor.   Karimullina, Elina; Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Aquat Toxicol (2012 Jul 15) 22466357 Exiting the NIEHS site 2012 
Introduction: use of radioactive compounds in drug discovery and development.   Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Mar 19) 22324508 Exiting the NIEHS site 2012 
Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.   Damiri, Basma; Holle, Eric; Yu, Xianzhong; Baldwin, William S R15ES017321, R15ES017321 Toxicol Sci (2012 Feb) 22083726 Exiting the NIEHS site 2012 
Mutation spectra of S-(2-hydroxy-3,4-epoxybutyl)glutathione: comparison with 1,3-butadiene and its m ...   Cho, Sung-Hee; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2012 Jul 16) 22670845 Exiting the NIEHS site 2012 
Replication of N2,3-ethenoguanine by DNA polymerases.   Zhao, Linlin; Christov, Plamen P; Kozekov, Ivan D; Pence, Matthew G; Pallan, Pradeep S; Rizzo, ... R01ES010546, T32ES007028 Angew Chem Int Ed Engl (2012 May 29) 22488769 Exiting the NIEHS site 2012 
1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched wi ...   Shanmugam, Ganesh; Kozekov, Ivan D; Guengerich, F Peter; Rizzo, Carmelo J; Stone, Michael P R01ES010546 Chem Res Toxicol (2011 Jul 18) 21675798 Exiting the NIEHS site 2011 
Liquid chromatography-mass spectrometry analysis of DNA polymerase reaction products.   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Curr Protoc Nucleic Acid Chem (2011 Dec) 22147421 Exiting the NIEHS site 2011 
Mechanisms of drug toxicity and relevance to pharmaceutical development.   Guengerich, F Peter R01ES010546 Drug Metab Pharmacokinet (2011) 20978361 Exiting the NIEHS site 2011 
Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes ...   Mota, Linda C; Barfield, Christina; Hernandez, Juan P; Baldwin, William S R15ES017321, R15ES017321 Toxicol Appl Pharmacol (2011 May 1) 21376070 Exiting the NIEHS site 2011 
Selective imaging and killing of cancer cells with protein-activated near-infrared fluorescing nanop ...   Rungta, Parul; Bandera, Yuriy P; Roeder, Ryan D; Li, Yangchun; Baldwin, William S; Sharma, Dee ... R15ES017321, R15ES017321 Macromol Biosci (2011 Jul 07) 21480531 Exiting the NIEHS site 2011 
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: associa ...   Mota, Linda C; Hernandez, Juan P; Baldwin, William S R15ES017321, R15ES017321 Drug Metab Dispos (2010 Sep) 20573718 Exiting the NIEHS site 2010 
Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) aft ...   Gonzalez, Horacio O; Hu, Jianjun; Gaworecki, Kristen M; Roling, Jonathan A; Baldwin, William S; ... R15ES017321, R15ES017321 Mar Environ Res (2010 Aug) 20451245 Exiting the NIEHS site 2010 
Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and format ...   Chowdhury, Goutam; Murayama, Norie; Okada, Yusuke; Uno, Yasuhiro; Shimizu, Makiko; Shibata, No ... R01ES010546 Chem Res Toxicol (2010 Jun 21) 20443640 Exiting the NIEHS site 2010 
Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: ...   Van Aggelen, Graham; Ankley, Gerald T; Baldwin, William S; Bearden, Daniel W; Benson, William H ... R15ES017321, R15ES017321 Environ Health Perspect (2010 Jan) 20056575 Exiting the NIEHS site 2010 
Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription ...   Hannas, Bethany R; Wang, Ying H; Baldwin, William S; Li, Yangchun; Wallace, Andrew D; LeBlanc, ... R15ES017321, R15ES017321, T32ES007046 Gen Comp Endocrinol (2010 Jun 1) 20346363 Exiting the NIEHS site 2010 
Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage.   Eoff, Robert L; Choi, Jeong-Yun; Guengerich, F Peter R01ES010546 J Nucleic Acids (2010 Sep 26) 20936119 Exiting the NIEHS site 2010 
Mutagenicity of a glutathione conjugate of butadiene diepoxide.   Cho, Sung-Hee; Loecken, Elisabeth M; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2010 Oct 18) 20879737 Exiting the NIEHS site 2010 
A concentration addition model for the activation of the constitutive androstane receptor by xenobio ...   Baldwin, William S; Roling, Jonathan A R15ES017321, R15ES017321 Toxicol Sci (2009 Jan) 18832183 Exiting the NIEHS site 2009 
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolis ...   Hernandez, J P; Mota, L C; Baldwin, W S R15ES017321, R15ES017321 Curr Pharmacogenomics Person Med (2009 Jun 1) 20871735 Exiting the NIEHS site 2009 
Inherent stereospecificity in the reaction of aflatoxin B(1) 8,9-epoxide with deoxyguanosine and eff ...   Brown, Kyle L; Bren, Urban; Stone, Michael P; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2009 May) 19301826 Exiting the NIEHS site 2009 
Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.   Knutson, Charles G; Rubinson, Emily H; Akingbade, Dapo; Anderson, Carolyn S; Stec, Donald F; Pe ... R01ES010546, T32ES007028 Biochemistry (2009 Feb 3) 19132922 Exiting the NIEHS site 2009 
Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).   Hernandez, J P; Mota, L C; Huang, W; Moore, D D; Baldwin, W S R15ES017321, R15ES017321 Toxicology (2009 Feb 4) 19041682 Exiting the NIEHS site 2009 
Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA f ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2009 Jul) 19496605 Exiting the NIEHS site 2009 
The bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced ...   Loecken, Elisabeth M; Dasari, Surendra; Hill, Salisha; Tabb, David L; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2009 Jun) 19364102 Exiting the NIEHS site 2009 
Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrome ...   Chowdhury, Goutam; Guengerich, F Peter R01ES010546 Angew Chem Int Ed Engl (2008) 18022988 Exiting the NIEHS site 2008 
Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehy ...   Bodreddigari, Sridevi; Jones, Laundette Knight; Egner, Patricia A; Groopman, John D; Sutter, Ca ... R01ES010546, T32ES007141 Chem Res Toxicol (2008 May) 18416522 Exiting the NIEHS site 2008 
Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produ ...   Loecken, Elisabeth M; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2008 Feb) 18163542 Exiting the NIEHS site 2008 
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.   Fang, Qingming; Noronha, Anne M; Murphy, Sebastian P; Wilds, Christopher J; Tubbs, Julie L; Tai ... R01ES010546 Biochemistry (2008 Oct 14) 18803403 Exiting the NIEHS site 2008 
Analysis of DNA adducts formed in vivo in rats and mice from 1,2-dibromoethane, 1,2-dichloroethane, ...   Watanabe, Kengo; Liberman, Rosa G; Skipper, Paul L; Tannenbaum, Steven R; Guengerich, F Peter P30ES002109, R01ES010546 Chem Res Toxicol (2007 Nov) 17907789 Exiting the NIEHS site 2007 
Applying mechanisms of chemical toxicity to predict drug safety.   Guengerich, F Peter; MacDonald, James S R01ES010546 Chem Res Toxicol (2007 Mar) 17302443 Exiting the NIEHS site 2007 
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its abi ...   Liu, Liping; Watanabe, Kengo; Fang, Qingming; Williams, Kevin M; Guengerich, F Peter; Pegg, An ... R01ES010546, T32ES007028 Chem Res Toxicol (2007 Jan) 17226938 Exiting the NIEHS site 2007 
Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations.   Bren, Urban; Guengerich, F Peter; Mavri, Janez R01ES010546 Chem Res Toxicol (2007 Aug) 17630712 Exiting the NIEHS site 2007 
Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and gu ...   Bren, Urban; Zupan, Mateja; Guengerich, F Peter; Mavri, Janez R01ES010546 J Org Chem (2006 May 26) 16709046 Exiting the NIEHS site 2006 
Cytochrome P450s and other enzymes in drug metabolism and toxicity.   Guengerich, F Peter R01ES010546 AAPS J (2006) 16584116 Exiting the NIEHS site 2006 
Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of d ...   Watanabe, Kengo; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2006 Aug) 16918250 Exiting the NIEHS site 2006 
Generation of reactive intermediates.   Guengerich, F Peter R01ES010546 J Biochem Mol Toxicol (2005) 15977199 Exiting the NIEHS site 2005 
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase ...   Zang, Hong; Fang, Qingming; Pegg, Anthony E; Guengerich, F Peter R01ES010546 J Biol Chem (2005 Sep 2) 16000301 Exiting the NIEHS site 2005 
Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophil ...   Guengerich, F Peter R01ES010546 Arch Biochem Biophys (2005 Jan 15) 15581593 Exiting the NIEHS site 2005 
Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferas ...   Valadez, J Gerardo; Liu, Liping; Loktionova, Natalia A; Pegg, Anthony E; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2004 Jul) 15257623 Exiting the NIEHS site 2004 
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alky ...   Liu, Liping; Hachey, David L; Valadez, Gerardo; Williams, Kevin M; Guengerich, F Peter; Loktion ... R01ES010546, T32ES007028 J Biol Chem (2004 Feb 6) 14645247 Exiting the NIEHS site 2004 
Cytochrome P450: what have we learned and what are the future issues?   Guengerich, F Peter R01ES010546 Drug Metab Rev (2004 May) 15237850 Exiting the NIEHS site 2004 
Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutat ...   Marsch, Glenn A; Botta, Sisir; Martin, Martha V; McCormick, W Andrew; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2004 Jan) 14727918 Exiting the NIEHS site 2004 
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromom ...   Liu, Liping; Williams, Kevin M; Guengerich, F Peter; Pegg, Anthony E R01ES010546, T32ES007028 Chem Res Toxicol (2004 Jun) 15206895 Exiting the NIEHS site 2004 
S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair ra ...   Valadez, J Gerardo; Guengerich, F Peter R01ES010546 J Biol Chem (2004 Apr 02) 14715658 Exiting the NIEHS site 2004 
Activation of dihaloalkanes by thiol-dependent mechanisms.   Guengerich, F Peter R01ES010546 J Biochem Mol Biol (2003 Jan 31) 12542971 Exiting the NIEHS site 2003 
Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione tra ...   Guengerich, F Peter; McCormick, W Andrew; Wheeler, James B R01ES010546 Chem Res Toxicol (2003 Nov) 14615977 Exiting the NIEHS site 2003 
Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methy ...   Woodside, Adrienne M; Guengerich, F Peter R01ES010546, T32ES007028 Biochemistry (2002 Jan 22) 11790127 Exiting the NIEHS site 2002 
Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide.   Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter R01ES010546, T32ES007028 Chem Res Toxicol (2002 Nov) 12437332 Exiting the NIEHS site 2002 
Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive po ...   Woodside, Adrienne M; Guengerich, F Peter R01ES010546, T32ES007028 Biochemistry (2002 Jan 22) 11790128 Exiting the NIEHS site 2002 
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase ...   Liu, Liping; Pegg, Anthony E; Williams, Kevin M; Guengerich, F Peter R01ES010546, T32ES007028 J Biol Chem (2002 Oct 4) 12151404 Exiting the NIEHS site 2002 
Reaction of aflatoxin B(1) oxidation products with lysine.   Guengerich, F Peter; Arneson, Kyle O; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M R01ES010546, T32ES007028 Chem Res Toxicol (2002 Jun) 12067245 Exiting the NIEHS site 2002 
Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine.   Guengerich, F Peter; Voehler, Markus; Williams, Kevin M; Deng, Zhengwu; Harris, Thomas M R01ES010546, T32ES007028 Chem Res Toxicol (2002 Jun) 12067246 Exiting the NIEHS site 2002 
Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine.   Yoshioka, Tadao; Krauser, Joel A; Guengerich, F Peter R01ES010546 Chem Res Toxicol (2002 Aug) 12184794 Exiting the NIEHS site 2002 
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalometh ...   Wheeler, J B; Stourman, N V; Thier, R; Dommermuth, A; Vuilleumier, S; Rose, J A; Armstrong, R ... R01ES010546 Chem Res Toxicol (2001 Aug) 11511186 Exiting the NIEHS site 2001 
Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal di ...   Wheeler, J B; Stourman, N V; Armstrong, R N; Guengerich, F P R01ES010546 Chem Res Toxicol (2001 Aug) 11511185 Exiting the NIEHS site 2001 
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