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Who We Fund: Publications associated with Organ Systems Or Disease Processes Research - Liver

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 66 publications
Export to Excel (http://www.niehs.nih.gov//portfolio/index.cfm/portfolio/sciencecodepubs/sc/55/topic/55/format/excel)
Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Develop ...   Schumacher, Justin D; Kong, Bo; Wu, Jason; Rizzolo, Daniel; Armstrong, Laura E; Chow, Monica D ... R21ES029258, T32ES007148, T32ES019854 Hepatology (2020 Feb) 31206730 Exiting the NIEHS site 2020 
Effects of total parenteral nutrition on drug metabolism gene expression in mice.   Ferrucci-Da Silva, Christina; Zhan, Le; Shen, Jianliang; Kong, Bo; Campbell, Michael J; Memon, ... P30ES005022, R21ES029258, T32ES007148 Acta Pharm Sin B (2020 Jan) 31993312 Exiting the NIEHS site 2020 
Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency.   Huang, Mingxing; Kong, Bo; Zhang, Min; Rizzolo, Daniel; Armstrong, Laura E; Schumacher, Justin ... R21ES029258, T32ES007148 Lab Invest (2020 May 13) 32404932 Exiting the NIEHS site 2020 
Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance.   Toth, Erica L; Clarke, John D; Csanaky, Iván L; Cherrington, Nathan J P30ES006694, R01ES028668, T32ES007091 Biochem Pharmacol (2020 Apr) 31881192 Exiting the NIEHS site 2020 
Is CYP2C70 the key to new mouse models to understand bile acids in humans?   Guo, Grace L; Chiang, John Y L R21ES029258, T32ES007148 J Lipid Res (2020 03) 31964761 Exiting the NIEHS site 2020 
A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcohol ...   Montonye, Michelle L; Tian, Dan-Dan; Arman, Tarana; Lynch, Katherine D; Hagenbuch, Bruno; Paine ... R00ES024455 J Pharmacol Exp Ther (2019 11) 31420525 Exiting the NIEHS site 2019 
Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mous ...   Rizzolo, Daniel; Buckley, Kyle; Kong, Bo; Zhan, Le; Shen, Jianliang; Stofan, Mary; Brinker, A ... P30ES005022, R21ES029258 Hepatology (2019 07) 30864232 Exiting the NIEHS site 2019 
Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transg ...   Poole, L G; Pant, A; Baker, K S; Kopec, A K; Cline-Fedewa, H M; Iismaa, S E; Flick, M J; Luye ... R01ES017537, T32ES007255 J Thromb Haemost (2019 01) 30415489 Exiting the NIEHS site 2019 
Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahe ...   Baker, Kevin S; Kopec, Anna K; Pant, Asmita; Poole, Lauren G; Cline-Fedewa, Holly; Ivkovich, D ... R01ES017537, T32ES007255 Arterioscler Thromb Vasc Biol (2019 10) 31412737 Exiting the NIEHS site 2019 
Endothelial force awakens a mechanism of portal hypertension: It's a neutrophil extracellular trap!   Groeneveld, Dafna J; Luyendyk, James P R01ES017537 J Thromb Haemost (2019 08) 31254323 Exiting the NIEHS site 2019 
FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injur ...   Kong, Bo; Zhang, Min; Huang, Mingxing; Rizzolo, Dan; Armstrong, Laura E; Schumacher, Justin D; ... R21ES029258, T32ES007148 Dig Liver Dis (2019 04) 30803859 Exiting the NIEHS site 2019 
Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.   Clarke, John D; Dzierlenga, Anika; Arman, Tarana; Toth, Erica; Li, Hui; Lynch, Katherine D; Ti ... R00ES024455 Toxicon (2019 Apr 15) 30849452 Exiting the NIEHS site 2019 
Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Stea ...   Schumacher, Justin D; Guo, Grace L R21ES029258, T32ES007148 Handb Exp Pharmacol (2019) 31201553 Exiting the NIEHS site 2019 
Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis i ...   Arman, Tarana; Lynch, Katherine D; Montonye, Michelle L; Goedken, Michael; Clarke, John D R00ES024455 Toxins (Basel) (2019 07 09) 31323923 Exiting the NIEHS site 2019 
The multifaceted role of fibrinogen in tissue injury and inflammation.   Luyendyk, James P; Schoenecker, Jonathan G; Flick, Matthew J R01ES017537 Blood (2019 02 07) 30523120 Exiting the NIEHS site 2019 
Understanding Environmental Contaminants' Direct Effects on Non-alcoholic Fatty Liver Disease Progre ...   Armstrong, Laura E; Guo, Grace L R21ES029258, T32ES007148 Curr Environ Health Rep (2019 09) 31090041 Exiting the NIEHS site 2019 
Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo.   Kopec, Anna K; Spada, Alfred P; Contreras, Patricia C; Mackman, Nigel; Luyendyk, James P R01ES017537 Toxicol Sci (2018 04 01) 29228388 Exiting the NIEHS site 2018 
Fibroblast Growth Factor 15-Dependent and Bile Acid-Independent Promotion of Liver Regeneration in M ...   Kong, Bo; Sun, Runbin; Huang, Mingxing; Chow, Monica D; Zhong, Xiao-Bo; Xie, Wen; Lee, Yi-Hor ... R21ES029258 Hepatology (2018 11) 29672888 Exiting the NIEHS site 2018 
FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice.   Zhang, Min; Kong, Bo; Huang, Mingxing; Wan, Ruixuan; Armstrong, Laura E; Schumacher, Justin D; ... R21ES029258, T32ES007148 Dig Liver Dis (2018 10) 29730159 Exiting the NIEHS site 2018 
Platelets as Modulators of Liver Diseases.   Lisman, Ton; Luyendyk, James P R01ES017537 Semin Thromb Hemost (2018 Mar) 28898899 Exiting the NIEHS site 2018 
Role of the blood coagulation cascade in hepatic fibrosis.   Pant, Asmita; Kopec, Anna K; Luyendyk, James P R01ES017537 Am J Physiol Gastrointest Liver Physiol (2018 08 01) 29723040 Exiting the NIEHS site 2018 
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellul ...   Joshi, Nikita; Ray, Jessica L; Kopec, Anna K; Luyendyk, James P R01ES017537 J Biochem Mol Toxicol (2017 Jan) 27605088 Exiting the NIEHS site 2017 
Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver ...   Clarke, John D; Novak, Petr; Lake, April D; Hardwick, Rhiannon N; Cherrington, Nathan J P30ES006694, R00ES024455, T32ES007091 Liver Int (2017 07) 28097795 Exiting the NIEHS site 2017 
In vivo cytochrome P450 activity alterations in diabetic nonalcoholic steatohepatitis mice.   Li, Hui; Clarke, John D; Dzierlenga, Anika L; Bear, John; Goedken, Michael J; Cherrington, Nat ... P30ES006694, R00ES024455, T32ES007091 J Biochem Mol Toxicol (2017 Feb) 27712037 Exiting the NIEHS site 2017 
Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis ...   Joshi, Nikita; Kopec, Anna K; Cline-Fedewa, Holly; Luyendyk, James P R01ES017537 Toxicology (2017 02 15) 28049044 Exiting the NIEHS site 2017 
Pediatric Cytochrome P450 Activity Alterations in Nonalcoholic Steatohepatitis.   Li, Hui; Canet, Mark J; Clarke, John D; Billheimer, Dean; Xanthakos, Stavra A; Lavine, Joel E; ... P30ES006694, R00ES024455, T32ES007091 Drug Metab Dispos (2017 12) 28986475 Exiting the NIEHS site 2017 
Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice.   Poole, Lauren G; Massey, Veronica L; Siow, Deanna L; Torres-Gonzáles, Edilson; Warner, Nikole L ... R01ES017537, T32ES011564 Am J Respir Cell Mol Biol (2017 09) 28445073 Exiting the NIEHS site 2017 
Targeting Phospholipase D4 Attenuates Kidney Fibrosis.   Trivedi, Priyanka; Kumar, Ramya K; Iyer, Ashwin; Boswell, Sarah; Gerarduzzi, Casimiro; Dadhania ... R01ES017537, R01ES017543, R01ES017543 J Am Soc Nephrol (2017 Dec) 28814511 Exiting the NIEHS site 2017 
Thrombin promotes diet-induced obesity through fibrin-driven inflammation.   Kopec, Anna K; Abrahams, Sara R; Thornton, Sherry; Palumbo, Joseph S; Mullins, Eric S; Divanovi ... R01ES017537 J Clin Invest (2017 Aug 01) 28737512 Exiting the NIEHS site 2017 
Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis.   Ray, Jessica L; Kopec, Anna K; Joshi, Nikita; Cline-Fedewa, Holly; Lash, Lawrence H; Williams, ... R01ES017537 Toxicol Sci (2017 04 01) 28115651 Exiting the NIEHS site 2017 
Von Willebrand factor deficiency reduces liver fibrosis in mice.   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Cline-Fedewa, Holly; Groeneveld, Dafna J; Lisman, ... R01ES017537 Toxicol Appl Pharmacol (2017 08 01) 28527913 Exiting the NIEHS site 2017 
Biliary Elimination of Pemetrexed Is Dependent on Mrp2 in Rats: Potential Mechanism of Variable Resp ...   Dzierlenga, Anika L; Clarke, John D; Klein, David M; Anumol, Tarun; Snyder, Shane A; Li, HongY ... P30ES006694, R00ES024455, T32ES007091 J Pharmacol Exp Ther (2016 08) 27233293 Exiting the NIEHS site 2016 
Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Cline-Fedewa, Holly; Nawabi, Atta; Schmitt, Timo ... R01ES017537 Blood (2016 06 02) 26921287 Exiting the NIEHS site 2016 
From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) i ...   Nault, Rance; Fader, Kelly A; Kopec, Anna K; Harkema, Jack R; Zacharewski, Timothy R; Luyendyk, ... R01ES017537 Toxicol Sci (2016 12) 27613713 Exiting the NIEHS site 2016 
Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver ...   Rautou, Pierre-Emmanuel; Tatsumi, Kohei; Antoniak, Silvio; Owens 3rd, A Phillip; Sparkenbaugh, ... R01ES017537 J Hepatol (2016 Jan) 26325534 Exiting the NIEHS site 2016 
Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathol ...   Joshi, Nikita; Kopec, Anna K; Ray, Jessica L; Luyendyk, James P R01ES017537 Toxicology (2016 07 15) 27475285 Exiting the NIEHS site 2016 
Nonalcoholic Steatohepatitis Modulates Membrane Protein Retrieval and Insertion Processes.   Dzierlenga, A L; Clarke, J D; Cherrington, N J P30ES006694, R00ES024455, T32ES007091 Drug Metab Dispos (2016 11) 27604106 Exiting the NIEHS site 2016 
RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.   Craciun, Florin L; Bijol, Vanesa; Ajay, Amrendra K; Rao, Poornima; Kumar, Ramya K; Hutchinson, ... R01ES017537, R01ES017543, R01ES017543 J Am Soc Nephrol (2016 06) 26449608 Exiting the NIEHS site 2016 
Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?   Kopec, Anna K; Luyendyk, James P R01ES017537 Semin Thromb Hemost (2016 Jun) 27144445 Exiting the NIEHS site 2016 
Role of hemostatic factors in hepatic injury and disease: animal models de-liver.   Kopec, A K; Joshi, N; Luyendyk, J P R01ES017537 J Thromb Haemost (2016 07) 27060337 Exiting the NIEHS site 2016 
A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic de ...   Ellery, Paul E R; Maroney, Susan A; Cooley, Brian C; Luyendyk, James P; Zogg, Mark; Weiler, Ha ... R01ES017537 Blood (2015 Jun 25) 25954015 Exiting the NIEHS site 2015 
Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.   Joshi, N; Kopec, A K; O'Brien, K M; Towery, K L; Cline-Fedewa, H; Williams, K J; Copple, B L; ... R01ES017537 J Thromb Haemost (2015 Jan) 25353084 Exiting the NIEHS site 2015 
Circulating microparticle tissue factor activity is increased in patients with cirrhosis.   Rautou, Pierre-Emmanuel; Vion, Anne-Clémence; Luyendyk, James P; Mackman, Nigel R01ES017537 Hepatology (2014 Nov) 24470301 Exiting the NIEHS site 2014 
Coagulation in liver toxicity and disease: role of hepatocyte tissue factor.   Kopec, Anna K; Luyendyk, James P R01ES017537 Thromb Res (2014 May) 24759146 Exiting the NIEHS site 2014 
Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.   Lopez, Michelle; Kopec, Anna K; Joshi, Nikita; Geddings, Julia E; Cline, Holly; Towery, Keara ... R01ES017537 Toxicol Sci (2014 Oct) 25015658 Exiting the NIEHS site 2014 
Hepatic stellate cells orchestrate clearance of necrotic cells in a hypoxia-inducible factor-1α-depe ...   Mochizuki, Akie; Pace, Aaron; Rockwell, Cheryl E; Roth, Katherine J; Chow, Aaron; O'Brien, Kat ... R01ES017537, T32ES007255 J Immunol (2014 Apr 15) 24639359 Exiting the NIEHS site 2014 
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy ...   Ni, Hong-Min; Woolbright, Benjamin L; Williams, Jessica; Copple, Bryan; Cui, Wei; Luyendyk, Ja ... R01ES017537 J Hepatol (2014 Sep) 24815875 Exiting the NIEHS site 2014 
The antifibrinolytic drug tranexamic acid reduces liver injury and fibrosis in a mouse model of chro ...   Joshi, Nikita; Kopec, Anna K; Towery, Keara; Williams, Kurt J; Luyendyk, James P R01ES017537 J Pharmacol Exp Ther (2014 Jun) 24633426 Exiting the NIEHS site 2014 
Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mi ...   Kopec, Anna K; Joshi, Nikita; Towery, Keara L; Kassel, Karen M; Sullivan, Bradley P; Flick, Ma ... R01ES017537 J Pharmacol Exp Ther (2014 Nov) 25138021 Exiting the NIEHS site 2014 
Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cho ...   Kopec, Anna K; Sullivan, Bradley P; Kassel, Karen M; Joshi, Nikita; Luyendyk, James P R01ES017537 Toxicol Sci (2014 Oct) 25055964 Exiting the NIEHS site 2014 
Hepatocyte tissue factor activates the coagulation cascade in mice.   Sullivan, Bradley P; Kopec, Anna K; Joshi, Nikita; Cline, Holly; Brown, Juliette A; Bishop, St ... R01ES017537 Blood (2013 Mar 07) 23305736 Exiting the NIEHS site 2013 
IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis.   O'Brien, Kate M; Allen, Katryn M; Rockwell, Cheryl E; Towery, Keara; Luyendyk, James P; Copple, ... R01ES017537, T32ES007255 Am J Pathol (2013 Nov) 24012680 Exiting the NIEHS site 2013 
Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis ...   Sullivan, Bradley P; Cui, Wei; Copple, Bryan L; Luyendyk, James P R01ES017537 Toxicol Sci (2012 Mar) 22094456 Exiting the NIEHS site 2012 
Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.   Sullivan, Bradley P; Kassel, Karen M; Jone, Alice; Flick, Matthew J; Luyendyk, James P R01ES017537 Am J Pathol (2012 Jun) 22507835 Exiting the NIEHS site 2012 
Lipopolysaccharide enhances transforming growth factor ýý1-induced platelet-derived growth factor-B ...   Kassel, Karen M; Sullivan, Bradley P; Luyendyk, James P R01ES017537 J Gastroenterol Hepatol (2012 Apr) 22004089 Exiting the NIEHS site 2012 
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation ...   Kassel, Karen M; Sullivan, Bradley P; Cui, Wei; Copple, Bryan L; Luyendyk, James P R01ES017537 Am J Pathol (2012 Oct) 22841818 Exiting the NIEHS site 2012 
Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocyte ...   Mei, Shuang; Ni, Hong-Min; Manley, Sharon; Bockus, Abigail; Kassel, Karen M; Luyendyk, James P ... R01ES017537 J Pharmacol Exp Ther (2011 Nov) 21856859 Exiting the NIEHS site 2011 
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a mod ...   Luyendyk, James P; Kassel, Karen M; Allen, Katryn; Guo, Grace L; Li, Guodong; Cantor, Glenn H; ... R01ES017537 Am J Pathol (2011 Mar) 21356363 Exiting the NIEHS site 2011 
Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosi ...   Kassel, Karen M; Owens 3rd, A Phillip; Rockwell, Cheryl E; Sullivan, Bradley P; Wang, Ruipeng; ... R01ES017537 Am J Pathol (2011 Nov) 21907177 Exiting the NIEHS site 2011 
Regulation of transforming growth factor-ýý1-dependent integrin ýý6 expression by p38 mitogen-activa ...   Sullivan, Bradley P; Kassel, Karen M; Manley, Sharon; Baker, Alyson K; Luyendyk, James P R01ES017537 J Pharmacol Exp Ther (2011 May) 21303922 Exiting the NIEHS site 2011 
Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver in ...   Luyendyk, James P; Mackman, Nigel; Sullivan, Bradley P R01ES017537 Toxicol Sci (2011 Jan) 20974703 Exiting the NIEHS site 2011 
Steatosis DeLIVERs high-sensitivity C-reactive protein.   Luyendyk, James P; Guo, Grace L R01ES017537 Arterioscler Thromb Vasc Biol (2011 Aug) 21775769 Exiting the NIEHS site 2011 
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mic ...   Luyendyk, James P; Flanagan, Kevin C; Williams, C David; Jaeschke, Hartmut; Slusser, Joyce G; M ... R01ES017537 Toxicol Appl Pharmacol (2011 Feb 01) 21070799 Exiting the NIEHS site 2011 
Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion ...   Sullivan, Bradley P; Wang, Ruipeng; Tawfik, Ossama; Luyendyk, James P R01ES017537 Toxicol Sci (2010 May) 20133375 Exiting the NIEHS site 2010 
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by ...   Sullivan, Bradley P; Weinreb, Paul H; Violette, Shelia M; Luyendyk, James P R01ES017537 Am J Pathol (2010 Dec) 21037076 Exiting the NIEHS site 2010 
Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic ...   Luyendyk, James P; Cantor, Glenn H; Kirchhofer, Daniel; Mackman, Nigel; Copple, Bryan L; Wang, ... R01ES017537 Am J Physiol Gastrointest Liver Physiol (2009 Apr) 19179621 Exiting the NIEHS site 2009 
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