Project Title: | ACTIVATED MACROPHAGES AND OZONE TOXICITY |
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PI: | Laskin, Debra L |
Institution: | Rutgers Biomedical And Health Sciences |
Grant Number: | R01ES004738 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based ... | Gutierrez, Bryan; Aggarwal, Tushar; Erguven, Huseyin; Stone, M Rhia L; Guo, Changjiang; Bellomo ... | P30ES005022, R01ES004738, R01ES033698, T32ES007148 | iScience (2023 Dec 15) | 38144454 | 2023 |
Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow c ... | Radbel, Jared; Meshanni, Jaclynn A; Gardner, Carol R; Le-Hoang, Oanh; Cervelli, Jessica; Laskin ... | K08ES031678, P30ES005022, R01ES004738, R01ES033698, T32ES007148 | Toxicol Appl Pharmacol (2023 Feb 01) | 36565939 | 2023 |
Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure. | Smith, Ley Cody; Gow, Andrew J; Abramova, Elena; Vayas, Kinal; Guo, Changjiang; Noto, Jack; Ly ... | P30ES005022, R00ES032473, R01ES004738, R25ES020721, T32ES007148 | Toxicol Sci (2023 Jun 28) | 37202362 | 2023 |
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation wi ... | Cary, Chelsea M; Seymore, Talia N; Singh, Dilpreet; Vayas, Kinal N; Goedken, Michael J; Adams, ... | P30ES005022, R01ES004738, R01ES031285, T32ES007148 | Part Fibre Toxicol (2023 Apr 23) | 37088832 | 2023 |
Targeting Tumor Necrosis Factor Alpha to Mitigate Lung Injury Induced by Mustard Vesicants and Radia ... | Malaviya, Rama; Laskin, Jeffrey D; Businaro, Rita; Laskin, Debra L | P30ES005022, R01ES004738, R01ES033698 | Disaster Med Public Health Prep (2023 Oct 18) | 37848400 | 2023 |
Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard expo ... | Murray, Alexa; Banota, Tanvi; Guo, Grace L; Smith, Ley Cody; Meshanni, Jaclynn A; Lee, Jordan; ... | P30ES005022, R01ES004738, R01ES033698, R25ES020721, T32ES007148 | Toxicol Appl Pharmacol (2022 Nov 01) | 35998709 | 2022 |
Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells foll ... | Sunil, Vasanthi R; Vayas, Kinal N; Radbel, Jared; Abramova, Elena; Gow, Andrew; Laskin, Jeffre ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2022 Dec 01) | 36174670 | 2022 |
Microvesicle-Derived miRNAs Regulate Proinflammatory Macrophage Activation in the Lung Following Ozo ... | Carnino, Jonathan M; Lee, Heedoo; Smith, Ley Cody; Sunil, Vasanthi R; Rancourt, Raymond C; Vaya ... | R00ES032473, R01ES004738, R01ES033698, T32ES007148 | Toxicol Sci (2022 Apr 26) | 35201360 | 2022 |
Regulation of macrophage activation by S-Nitrosothiols following ozone-induced lung injury. | Taylor, Sheryse; Murray, Alexa; Francis, Mary; Abramova, Elena; Guo, Changjiang; Laskin, Debra ... | P30ES005022, R01ES004738, R01ES033698, T32ES007148 | Toxicol Appl Pharmacol (2022 Dec 15) | 36244437 | 2022 |
Macrophage activation in the lung during the progression of nitrogen mustard induced injury is assoc ... | Venosa, Alessandro; Smith, L Cody; Gow, Andrew J; Zarbl, Helmut; Laskin, Jeffrey D; Laskin, De ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2021 07 15) | 33971176 | 2021 |
Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by an ... | Malaviya, Rama; Bellomo, Alyssa; Abramova, Elena; Croutch, Claire R; Roseman, Julie; Tuttle, R ... | P30ES005022, R01ES004738, R25ES020721, T32ES007148 | Toxicol Appl Pharmacol (2021 10 01) | 34390737 | 2021 |
Assessment of mustard vesicant lung injury and anti-TNF-α efficacy in rodents using live-animal imag ... | Murray, Alexa; Gow, Andrew J; Venosa, Alessandro; Andres, Jaclynn; Malaviya, Rama; Adler, Dere ... | P30ES005022, R01ES004738, T32ES007148 | Ann N Y Acad Sci (2020 11) | 33165947 | 2020 |
Chemical warfare agent research in precision-cut tissue slices-a useful alternative approach. | Herbert, Julia; Laskin, Debra L; Gow, Andrew J; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Ann N Y Acad Sci (2020 Nov) | 32808309 | 2020 |
Disease-modifying treatment of chemical threat agent-induced acute lung injury. | Radbel, Jared; Laskin, Debra L; Laskin, Jeffrey D; Kipen, Howard M | P30ES005022, R01ES004738, R01ES033698 | Ann N Y Acad Sci (2020 Nov) | 32726497 | 2020 |
DNA damage signaling in the cellular responses to mustard vesicants. | Jan, Yi-Hua; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Toxicol Lett (2020 Jun 15) | 32173488 | 2020 |
Long-term Respiratory Effects of Mustard Vesicants. | Malaviya, Rama; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Lett (2020 Feb 01) | 31698045 | 2020 |
Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard. | Sunil, Vasanthi R; Vayas, Kinal N; Abramova, Elena V; Rancourt, Raymond; Cervelli, Jessica A; M ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2020 01 15) | 31678244 | 2020 |
NETs: a new biomarker of traffic-related air pollution exposure: are they ready to catch fish? | Kipen, Howard M; Laskin, Debra L | P30ES005022, R01ES004738 | Eur Respir J (2020 Apr) | 32245775 | 2020 |
Nutraceuticals as potential therapeutics for vesicant-induced pulmonary fibrosis. | Businaro, Rita; Maggi, Elisa; Armeli, Federica; Murray, Alexa; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Ann N Y Acad Sci (2020 Nov) | 32725637 | 2020 |
Progressive Lung Injury, Inflammation, and Fibrosis in Rats Following Inhalation of Sulfur Mustard. | Malaviya, Rama; Abramova, Elena V; Rancourt, Raymond C; Sunil, Vasanthi R; Napierala, Marta; We ... | P30ES005022, R01ES004738 | Toxicol Sci (2020 Dec 01) | 33002157 | 2020 |
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms. | Malaviya, Rama; Kipen, Howard M; Businaro, Rita; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, R01ES033698 | Toxicol Appl Pharmacol (2020 Dec 15) | 33031836 | 2020 |
Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid ... | Francis, Mary; Guo, Grace; Kong, Bo; Abramova, Elena V; Cervelli, Jessica A; Gow, Andrew J; La ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2020 Oct 01) | 32984886 | 2020 |
Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pul ... | Andres, Jaclynn; Smith, Ley Cody; Murray, Alexa; Jin, Yang; Businaro, Rita; Laskin, Jeffrey D; ... | P30ES005022, R01ES004738, T32ES007148 | Cytokine Growth Factor Rev (2020 Feb) | 31901309 | 2020 |
The amplex red/horseradish peroxidase assay requires superoxide dismutase to measure hydrogen peroxi ... | Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Free Radic Res (2020 Sep) | 32912004 | 2020 |
Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard. | Smith, L Cody; Venosa, Alessandro; Gow, Andrew J; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Ann N Y Acad Sci (2020 11) | 32767459 | 2020 |
Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis ... | Venosa, Alessandro; Smith, Ley Cody; Murray, Alexa; Banota, Tanvi; Gow, Andrew J; Laskin, Jeff ... | P30ES005022, R01ES004738, R25ES020721, T32ES007148 | Toxicol Sci (2019 Dec 01) | 31428777 | 2019 |
Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants. | Laskin, Debra L; Malaviya, Rama; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Toxicol Sci (2019 Apr 01) | 30590802 | 2019 |
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progressi ... | Jan, Yi-Hua; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Chem Res Toxicol (2019 06 17) | 30964658 | 2019 |
Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflamm ... | Lee, Heedoo; Zhang, Duo; Laskin, Debra L; Jin, Yang | P30ES005022, R01ES004738 | J Immunol (2018 Sep 01) | 29997122 | 2018 |
Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. | Szilagyi, John T; Fussell, Karma C; Wang, Yun; Jan, Yi-Hua; Mishin, Vladimir; Richardson, Jaso ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2018 11 15) | 30222979 | 2018 |
Anti-TNFα therapy in inflammatory lung diseases. | Malaviya, Rama; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Pharmacol Ther (2017 Dec) | 28642115 | 2017 |
Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. | Yang, Shaojun; Jan, Yi-Hua; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey ... | P30ES005022, R01ES004738 | Chem Res Toxicol (2017 07 17) | 28595002 | 2017 |
Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury foll ... | Francis, Mary; Groves, Angela M; Sun, Richard; Cervelli, Jessica A; Choi, Hyejeong; Laskin, Je ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2017 02) | 27837169 | 2017 |
Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury ... | Francis, Mary; Sun, Richard; Cervelli, Jessica A; Choi, Hyejeong; Mandal, Mili; Abramova, Elen ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2017 01) | 27708193 | 2017 |
Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with c ... | Massa, Christopher B; Groves, Angela M; Jaggernauth, Smita U; Laskin, Debra L; Gow, Andrew J | P30ES005022, R01ES004738, T32ES007148 | PLoS Comput Biol (2017 Aug) | 28837561 | 2017 |
Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacet ... | Venosa, Alessandro; Gow, James G; Hall, LeRoy; Malaviya, Rama; Gow, Andrew J; Laskin, Jeffrey ... | P30ES005022, R01ES004738 | Toxicol Sci (2017 May 01) | 28184907 | 2017 |
World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and ... | Sunil, Vasanthi R; Vayas, Kinal N; Fang, Mingzhu; Zarbl, Helmut; Massa, Christopher; Gow, Andr ... | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2017 02) | 27986442 | 2017 |
Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury a ... | Venosa, Alessandro; Malaviya, Rama; Choi, Hyejeong; Gow, Andrew J; Laskin, Jeffrey D; Laskin, ... | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (2016 Mar) | 26273949 | 2016 |
Inflammatory mechanisms of pulmonary injury induced by mustards. | Malaviya, Rama; Sunil, Vasanthi R; Venosa, Alessandro; Vayas, Kinal N; Heck, Diane E; Laskin, ... | P30ES005022, R01ES004738 | Toxicol Lett (2016 Feb 26) | 26478570 | 2016 |
Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants. | Malaviya, Rama; Sunil, Vasanthi R; Venosa, Alessandro; Vayas, Kinal N; Businaro, Rita; Heck, D ... | P30ES005022, R01ES004738 | Ann N Y Acad Sci (2016 06) | 27351588 | 2016 |
Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. | Composto, Gabriella M; Laskin, Jeffrey D; Laskin, Debra L; Gerecke, Donald R; Casillas, Robert ... | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2016 06) | 27189522 | 2016 |
Mustard vesicant-induced lung injury: Advances in therapy. | Weinberger, Barry; Malaviya, Rama; Sunil, Vasanthi R; Venosa, Alessandro; Heck, Diane E; Laskin ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2016 08 15) | 27212445 | 2016 |
Mustard vesicants alter expression of the endocannabinoid system in mouse skin. | Wohlman, Irene M; Composto, Gabriella M; Heck, Diane E; Heindel, Ned D; Lacey, C Jeffrey; Guill ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2016 07 15) | 27125198 | 2016 |
Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-A ... | Udasin, Ronald G; Wen, Xia; Bircsak, Kristin M; Aleksunes, Lauren M; Shakarjian, Michael P; Kon ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2016 Jan) | 26454883 | 2016 |
Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodon ... | Szilagyi, John T; Mishin, Vladimir; Heck, Diane E; Jan, Yi-Hua; Aleksunes, Lauren M; Richardson ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2016 May) | 26880746 | 2016 |
The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liv ... | Mandal, Mili; Gardner, Carol R; Sun, Richard; Choi, Hyejeong; Lad, Sonali; Mishin, Vladimir; L ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2016 08 01) | 27163765 | 2016 |
Attenuation of Nitrogen Mustard-Induced Pulmonary Injury and Fibrosis by Anti-Tumor Necrosis Factor- ... | Malaviya, Rama; Sunil, Vasanthi R; Venosa, Alessandro; Verissimo, Vivianne L; Cervelli, Jessica ... | P30ES005022, R01ES004738 | Toxicol Sci (2015 Nov) | 26243812 | 2015 |
Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by ... | Venosa, Alessandro; Malaviya, Rama; Gow, Andrew J; Hall, Leroy; Laskin, Jeffrey D; Laskin, Deb ... | P30ES005022, R01ES004738 | Am J Physiol Lung Cell Mol Physiol (2015 Dec 15) | 26475734 | 2015 |
Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and ... | Malaviya, Rama; Gow, Andrew J; Francis, Mary; Abramova, Elena V; Laskin, Jeffrey D; Laskin, De ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2015 Mar) | 25552309 | 2015 |
Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galecti ... | Sunil, Vasanthi R; Francis, Mary; Vayas, Kinal N; Cervelli, Jessica A; Choi, Hyejeong; Laskin, ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2015 Apr 15) | 25724551 | 2015 |
Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. | Yang, Shaojun; Jan, Yi-Hua; Mishin, Vladimir; Richardson, Jason R; Hossain, Muhammad M; Heindel ... | P30ES005022, R01ES004738 | J Pharmacol Exp Ther (2015 Mar) | 25550200 | 2015 |
Thioredoxin Cross-Linking by Nitrogen Mustard in Lung Epithelial Cells: Formation of Multimeric Thio ... | Jan, Yi-Hua; Heck, Diane E; Casillas, Robert P; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Chem Res Toxicol (2015 Nov 16) | 26451472 | 2015 |
Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parat ... | Jan, Yi-Hua; Richardson, Jason R; Baker, Angela A; Mishin, Vladimir; Heck, Diane E; Laskin, De ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2015 Oct 01) | 26212258 | 2015 |
Acetaminophen reactive intermediates target hepatic thioredoxin reductase. | Jan, Yi-Hua; Heck, Diane E; Dragomir, Ana-Cristina; Gardner, Carol R; Laskin, Debra L; Laskin, ... | P30ES005022, R01ES004738 | Chem Res Toxicol (2014 May 19) | 24661219 | 2014 |
Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfacta ... | Massa, Christopher B; Scott, Pamela; Abramova, Elena; Gardner, Carol; Laskin, Debra L; Gow, An ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2014 Jul 1) | 24582687 | 2014 |
Critical role of the endogenous interferon ligand-receptors in type I and type II interferons respon ... | Lasfar, Ahmed; Cook, Jeffry R; Cohen Solal, Karine A; Reuhl, Kenneth; Kotenko, Sergei V; Langer ... | P30ES005022, R01ES004738 | Immunology (2014 Jul) | 24597649 | 2014 |
Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-c ... | Jan, Yi-Hua; Heck, Diane E; Malaviya, Rama; Casillas, Robert P; Laskin, Debra L; Laskin, Jeffr ... | P30ES005022, R01ES004738 | Chem Res Toxicol (2014 Jan 21) | 24274902 | 2014 |
Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. | Zheng, Ruijin; Dragomir, Ana-Cristina; Mishin, Vladimir; Richardson, Jason R; Heck, Diane E; La ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2014 Aug 15) | 24832492 | 2014 |
Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities d ... | Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Toxicol Sci (2014 Oct) | 25061110 | 2014 |
Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end ... | Zheng, Ruijin; Heck, Diane E; Mishin, Vladimir; Black, Adrienne T; Shakarjian, Michael P; Kong, ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2014 Mar 1) | 24423726 | 2014 |
Oxidative stress-induced autophagy: role in pulmonary toxicity. | Malaviya, Rama; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2014 Mar 1) | 24398106 | 2014 |
Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammat ... | Sunil, Vasanthi R; Vayas, Kinal N; Cervelli, Jessica A; Malaviya, Rama; Hall, LeRoy; Massa, Ch ... | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2014 Aug) | 24886962 | 2014 |
Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitro ... | Zheng, Ruijin; Heck, Diane E; Black, Adrienne T; Gow, Andrew; Laskin, Debra L; Laskin, Jeffrey ... | P30ES005022, R01ES004738 | Free Radic Biol Med (2014 Feb) | 24140437 | 2014 |
Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sul ... | Joseph, Laurie B; Heck, Diane E; Cervelli, Jessica A; Composto, Gabriella M; Babin, Michael C; ... | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2014 Jun) | 24662110 | 2014 |
Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent a ... | Chang, Yoke-Chen; Wang, James D; Hahn, Rita A; Gordon, Marion K; Joseph, Laurie B; Heck, Diane ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2014 Oct 15) | 25127551 | 2014 |
Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressi ... | Groves, Angela M; Gow, Andrew J; Massa, Christopher B; Hall, LeRoy; Laskin, Jeffrey D; Laskin, ... | P30ES005022, R01ES004738, T32ES007148 | Am J Physiol Lung Cell Mol Physiol (2013 Oct 15) | 23997172 | 2013 |
Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory sti ... | Liu, Yinglin; Gardner, Carol R; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Exp Mol Pathol (2013 Feb) | 23103612 | 2013 |
Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4. | Connor, Agnieszka J; Chen, Li C; Joseph, Laurie B; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2013 Feb) | 23000425 | 2013 |
Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric ... | D'Addio, Suzanne M; Baldassano, Steven; Shi, Lei; Cheung, Lila; Adamson, Douglas H; Bruzek, Ma ... | P30ES005022, R01ES004738 | J Control Release (2013 May 28) | 23419950 | 2013 |
Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulm ... | Sunil, Vasanthi R; Vayas, Kinal N; Massa, Christopher B; Gow, Andrew J; Laskin, Jeffrey D; Lask ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Sci (2013 Jun) | 23492811 | 2013 |
Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. | Yang, Shaojun; Jan, Yi-Hua; Gray, Joshua P; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; ... | P30ES005022, R01ES004738 | J Biol Chem (2013 Jun 28) | 23640889 | 2013 |
The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit corne ... | Zheng, Ruijin; Po, Iris; Mishin, Vladimir; Black, Adrienne T; Heck, Diane E; Laskin, Debra L; ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2013 Oct 15) | 23845594 | 2013 |
Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications f ... | Kutscher, H L; Gao, D; Li, S; Massa, C B; Cervelli, J; Deshmukh, M; Joseph, L B; Laskin, D L ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2013 Jan 15) | 23142466 | 2013 |
Attenuation of acute nitrogen mustard-induced lung injury, inflammation and fibrogenesis by a nitric ... | Malaviya, Rama; Venosa, Alessandro; Hall, Leroy; Gow, Andrew J; Sinko, Patrick J; Laskin, Jeff ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2012 Dec 15) | 22981630 | 2012 |
Biodistribution and renal clearance of biocompatible lung targeted poly(ethylene glycol) (PEG) nanog ... | Deshmukh, Manjeet; Kutscher, Hilliard L; Gao, Dayuan; Sunil, Vasanthi R; Malaviya, Rama; Vayas, ... | P30ES005022, R01ES004738 | J Control Release (2012 Nov 28) | 23041417 | 2012 |
Classical and alternative macrophage activation in the lung following ozone-induced oxidative stress ... | Sunil, Vasanthi R; Patel-Vayas, Kinal; Shen, Jianliang; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2012 Sep 01) | 22727909 | 2012 |
Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. | Gardner, Carol R; Mishin, Vladimir; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Sci (2012 Feb) | 22048645 | 2012 |
Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4. | Connor, Agnieszka J; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Exp Mol Pathol (2012 Apr) | 22300504 | 2012 |
Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflamma ... | Groves, Angela M; Gow, Andrew J; Massa, Christopher B; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Am J Respir Cell Mol Biol (2012 Dec) | 22878412 | 2012 |
Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by ... | Gardner, Carol R; Hankey, Pamela; Mishin, Vladimir; Francis, Mary; Yu, Shan; Laskin, Jeffrey D ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2012 Jul 15) | 22575169 | 2012 |
Role of galectin-3 in acetaminophen-induced hepatotoxicity and inflammatory mediator production. | Dragomir, Ana-Cristina; Sun, Richard; Mishin, Vladimir; Hall, LeRoy B; Laskin, Jeffrey D; Laski ... | P30ES005022, R01ES004738 | Toxicol Sci (2012 Jun) | 22461450 | 2012 |
Role of galectin-3 in classical and alternative macrophage activation in the liver following acetami ... | Dragomir, Ana-Cristina Docan; Sun, Richard; Choi, Hyejeong; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | J Immunol (2012 Dec 15) | 23175698 | 2012 |
Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced ... | Sunil, Vasanthi R; Shen, Jianliang; Patel-Vayas, Kinal; Gow, Andrew J; Laskin, Jeffrey D; Laski ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2012 May 15) | 22446026 | 2012 |
Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary ... | Kipen, Howard M; Gandhi, Sampada; Rich, David Q; Ohman-Strickland, Pamela; Laumbach, Robert; Fa ... | P30ES005022, R01ES004738 | Environ Health Perspect (2011 May) | 21163722 | 2011 |
Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. | Sunil, Vasanthi R; Patel, Kinal J; Shen, Jianliang; Reimer, David; Gow, Andrew J; Laskin, Jeff ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2011 Jan 01) | 20883710 | 2011 |
Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of ... | Dragomir, Ana-Cristina; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2011 Jun 15) | 21513726 | 2011 |
Macrophages and tissue injury: agents of defense or destruction? | Laskin, Debra L; Sunil, Vasanthi R; Gardner, Carol R; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Annu Rev Pharmacol Toxicol (2011) | 20887196 | 2011 |
Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cyt ... | Fussell, Karma C; Udasin, Ronald G; Gray, Joshua P; Mishin, Vladimir; Smith, Peter J S; Heck, ... | P30ES005022, R01ES004738, T32ES007148 | Free Radic Biol Med (2011 Apr 01) | 21215309 | 2011 |
Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae follow ... | Black, Adrienne T; Hayden, Patrick J; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sin ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2011 Jun 1) | 21457723 | 2011 |
Role of protein transamidation in serotonin-induced proliferation and migration of pulmonary artery ... | Liu, Yinglin; Wei, Lin; Laskin, Debra L; Fanburg, Barry L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (2011 Apr) | 20558776 | 2011 |
Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, ... | Sunil, Vasanthi R; Patel-Vayas, Kinal; Shen, Jianliang; Gow, Andrew J; Laskin, Jeffrey D; Laski ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2011 Feb 01) | 21070800 | 2011 |
Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with ... | Joseph, Laurie B; Gerecke, Donald R; Heck, Diane E; Black, Adrienne T; Sinko, Patrick J; Cervel ... | P30ES005022, R01ES004738 | Exp Mol Pathol (2011 Oct) | 21672537 | 2011 |
Sulfur mustard-induced pulmonary injury: therapeutic approaches to mitigating toxicity. | Weinberger, Barry; Laskin, Jeffrey D; Sunil, Vasanthi R; Sinko, Patrick J; Heck, Diane E; Laski ... | P30ES005022, R01ES004738 | Pulm Pharmacol Ther (2011 Feb) | 20851203 | 2011 |
UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelia ... | Black, Adrienne T; Gordon, Marion K; Heck, Diane E; Gallo, Michael A; Laskin, Debra L; Laskin, ... | P30ES005022, R01ES004738 | Biochem Pharmacol (2011 Apr 01) | 21300015 | 2011 |
Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation b ... | Mishin, Vladimir; Gray, Joshua P; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Free Radic Biol Med (2010 Jun 01) | 20188819 | 2010 |
Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity. | Wang, Yun; Gray, Joshua P; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Mol Cancer Ther (2010 Jun) | 20501808 | 2010 |
Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent follo ... | Black, Adrienne T; Hayden, Patrick J; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sin ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2010 Dec 01) | 20840853 | 2010 |
Inflammatory effects of inhaled sulfur mustard in rat lung. | Malaviya, Rama; Sunil, Vasanthi R; Cervelli, Jessica; Anderson, Dana R; Holmes, Wesley W; Conti ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2010 Oct 15) | 20659490 | 2010 |
Inflammatory effects of phthalates in neonatal neutrophils. | Vetrano, Anna M; Laskin, Debra L; Archer, Faith; Syed, Kirin; Gray, Joshua P; Laskin, Jeffrey ... | P30ES005022, R01ES004738 | Pediatr Res (2010 Aug) | 20453712 | 2010 |
Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl eth ... | Gray, Joshua P; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2010 Sep 01) | 20561902 | 2010 |
Janus kinase-3 dependent inflammatory responses in allergic asthma. | Malaviya, Rama; Laskin, Debra L; Malaviya, Ravi | P30ES005022, R01ES004738 | Int Immunopharmacol (2010 Aug) | 20430118 | 2010 |
Macrophages, reactive nitrogen species, and lung injury. | Laskin, Debra L; Sunil, Vasanthi R; Fakhrzadeh, Ladan; Groves, Angela; Gow, Andrew J; Laskin, ... | P30ES005022, R01ES004738, T32ES007148 | Ann N Y Acad Sci (2010 Aug) | 20716284 | 2010 |
Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure. | Shakarjian, Michael P; Heck, Diane E; Gray, Joshua P; Sinko, Patrick J; Gordon, Marion K; Casil ... | P30ES005022, R01ES004738 | Toxicol Sci (2010 Mar) | 19833738 | 2010 |
Oxidants and antioxidants in sulfur mustard-induced injury. | Laskin, Jeffrey D; Black, Adrienne T; Jan, Yi-Hua; Sinko, Patrick J; Heindel, Ned D; Sunil, Va ... | P30ES005022, R01ES004738, T32ES007148 | Ann N Y Acad Sci (2010 Aug) | 20716289 | 2010 |
Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. | Gardner, Carol R; Gray, Joshua P; Joseph, Laurie B; Cervelli, Jessica; Bremer, Nicole; Kim, Yu ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2010 May 15) | 20100502 | 2010 |
Pulmonary effects of inhaled diesel exhaust in young and old mice: a pilot project. | Laskin, Debra L; Mainelis, Gediminas; Turpin, Barbara J; Patel, Kinal J; Sunil, Vasanthi R; HEI ... | P30ES005022, R01ES004738 | Res Rep Health Eff Inst (2010 Sep) | 21381634 | 2010 |
Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse ker ... | Black, Adrienne T; Joseph, Laurie B; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sink ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2010 Jun 15) | 20382172 | 2010 |
Role of STK in mouse liver macrophage and endothelial cell responsiveness during acute endotoxemia. | Laskin, Debra L; Chen, Li; Hankey, Pamela A; Laskin, Jeffrey D | P30ES005022, R01ES004738 | J Leukoc Biol (2010 Aug) | 20453108 | 2010 |
Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl eth ... | Jan, Yi-Hua; Heck, Diane E; Gray, Joshua P; Zheng, Haiyan; Casillas, Robert P; Laskin, Debra L ... | P30ES005022, R01ES004738, T32ES007148 | Chem Res Toxicol (2010 Jun 21) | 20345183 | 2010 |
Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time re ... | Gerecke, Donald R; Chen, Minjun; Isukapalli, Sastry S; Gordon, Marion K; Chang, Yoke-Chen; Tong ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2009 Jan 15) | 18955075 | 2009 |
Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. | Laskin, Debra L | P30ES005022, R01ES004738 | Chem Res Toxicol (2009 Aug) | 19645497 | 2009 |
Nitrative and oxidative stress in toxicology and disease. | Roberts, Ruth A; Laskin, Debra L; Smith, Charles V; Robertson, Fredika M; Allen, Erin M G; Door ... | P30ES005022, R01ES004738 | Toxicol Sci (2009 Nov) | 19656995 | 2009 |
Pulmonary effects of inhaled diesel exhaust in aged mice. | Sunil, Vasanthi R; Patel, Kinal J; Mainelis, Gediminas; Turpin, Barbara J; Ridgely, Sherritta; ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2009 Dec 15) | 19729031 | 2009 |
Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model. | Chang, Yoke-Chen; Sabourin, Carol L K; Lu, Shou-En; Sasaki, Takako; Svoboda, Kathy K H; Gordon, ... | P30ES005022, R01ES004738 | J Biochem Mol Toxicol (2009 May-Jun) | 19526566 | 2009 |
Distinct effects of ultraviolet B light on antioxidant expression in undifferentiated and differenti ... | Black, Adrienne T; Gray, Joshua P; Shakarjian, Michael P; Laskin, Debra L; Heck, Diane E; Laski ... | P30ES005022, R01ES004738 | Carcinogenesis (2008 Jan) | 17984112 | 2008 |
Increased oxidative stress and antioxidant expression in mouse keratinocytes following exposure to p ... | Black, Adrienne T; Gray, Joshua P; Shakarjian, Michael P; Laskin, Debra L; Heck, Diane E; Laski ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2008 Sep 15) | 18620719 | 2008 |
Mechanisms mediating reduced responsiveness of neonatal neutrophils to lipoxin A4. | Weinberger, Barry; Quizon, Cecile; Vetrano, Anna M; Archer, Faith; Laskin, Jeffrey D; Laskin, ... | P30ES005022, R01ES004738 | Pediatr Res (2008 Oct) | 18535486 | 2008 |
Regulation of caveolin-1 expression, nitric oxide production and tissue injury by tumor necrosis fac ... | Fakhrzadeh, Ladan; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2008 Mar 15) | 18207479 | 2008 |
Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. | Chen, Li C; Laskin, Jeffrey D; Gordon, Marion K; Laskin, Debra L | P30ES005022, R01ES004738 | Exp Mol Pathol (2008 Apr) | 18222421 | 2008 |
Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. | Wang, Yun; Gray, Joshua P; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Free Radic Biol Med (2008 Mar 15) | 18206659 | 2008 |
UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. | Black, Adrienne T; Gray, Joshua P; Shakarjian, Michael P; Mishin, Vladimir; Laskin, Debra L; He ... | P30ES005022, R01ES004738, T32ES007148 | Toxicol Appl Pharmacol (2008 Oct 01) | 18597804 | 2008 |
Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. | Sunil, Vasanthi R; Patel, Kinal J; Nilsen-Hamilton, Marit; Heck, Diane E; Laskin, Jeffrey D; La ... | P30ES005022, R01ES004738 | Exp Mol Pathol (2007 Oct) | 17490638 | 2007 |
Influence of labor on neonatal neutrophil apoptosis, and inflammatory activity. | Weinberger, Barry; Vetrano, Anna M; Syed, Kirin; Murthy, Sowmya; Hanna, Nazeeh; Laskin, Jeffre ... | P30ES005022, R01ES004738 | Pediatr Res (2007 May) | 17413861 | 2007 |
Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an ... | Gray, Joshua P; Heck, Diane E; Mishin, Vladimir; Smith, Peter J S; Hong, Jun-Yan; Thiruchelvam, ... | P30ES005022, R01ES004738 | J Biol Chem (2007 Mar 16) | 17229725 | 2007 |
Pulmonary effects of inhaled limonene ozone reaction products in elderly rats. | Sunil, Vasanthi R; Laumbach, Robert J; Patel, Kinal J; Turpin, Barbara J; Lim, Ho-Jin; Kipen, ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2007 Jul 15) | 17610924 | 2007 |
Role of TLR-4 in liver macrophage and endothelial cell responsiveness during acute endotoxemia. | Chen, Li C; Gordon, Ronald E; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Exp Mol Pathol (2007 Dec) | 17996232 | 2007 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator pro ... | Dambach, Donna M; Durham, Stephen K; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2006 Mar 1) | 16081117 | 2006 |
Characterization of the oxidase activity in mammalian catalase. | Vetrano, Anna M; Heck, Diane E; Mariano, Thomas M; Mishin, Vladimir; Laskin, Debra L; Laskin, ... | P30ES005022, R01ES004738 | J Biol Chem (2005 Oct 21) | 16079130 | 2005 |
Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratin ... | Martey, Christine A; Vetrano, Anna M; Whittemore, Marilyn S; Mariano, Thomas M; Heck, Diane E; ... | P30ES005022, R01ES004738 | Biochem Pharmacol (2005 Dec 5) | 16259964 | 2005 |
Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypep ... | Weinberger, Barry; Hanna, Nazeeh; Laskin, Jeffrey D; Heck, Diane E; Gardner, Carol R; Gerecke, ... | P30ES005022, R01ES004738 | Mediators Inflamm (2005 Feb 24) | 15770064 | 2005 |
Mechanisms underlying reduced apoptosis in neonatal neutrophils. | Hanna, Nazeeh; Vasquez, Pedro; Pham, Petra; Heck, Diane E; Laskin, Jeffrey D; Laskin, Debra L; ... | P30ES005022, R01ES004738 | Pediatr Res (2005 Jan) | 15557111 | 2005 |
Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. | Laumbach, Robert J; Fiedler, Nancy; Gardner, Carol R; Laskin, Debra L; Fan, Zhi-Hua; Zhang, Ju ... | P30ES005022, R01ES004738 | J Occup Environ Med (2005 Nov) | 16282880 | 2005 |
Ozone-induced production of nitric oxide and TNF-alpha and tissue injury are dependent on NF-kappaB ... | Fakhrzadeh, Ladan; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Am J Physiol Lung Cell Mol Physiol (2004 Aug) | 15064226 | 2004 |
Solar ultraviolet radiation as a trigger of cell signal transduction. | Heck, Diane E; Gerecke, Donald R; Vetrano, Anna M; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2004 Mar 15) | 15020191 | 2004 |
Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases ... | Fakhrzadeh, Ladan; Laskin, Jeffrey D; Gardner, Carol R; Laskin, Debra L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (2004 Mar) | 12855403 | 2004 |
Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potent ... | Gardner, Carol R; Laskin, Jeffrey D; Dambach, Donna M; Chiu, Hawjyh; Durham, Stephen K; Zhou, ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2003 Oct 15) | 14550746 | 2003 |
Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense. | Chiu, Hawjyh; Gardner, Carol R; Dambach, Donna M; Brittingham, Jennie A; Durham, Stephen K; Las ... | P30ES005022, R01ES004738 | Am J Physiol Gastrointest Liver Physiol (2003 Nov) | 12842828 | 2003 |
Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-indu ... | Chiu, Hawjyh; Gardner, Carol R; Dambach, Donna M; Durham, Stephen K; Brittingham, Jennie A; Las ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2003 Dec 01) | 14644624 | 2003 |
Activation of adherent vascular neutrophils in the lung during acute endotoxemia. | Sunil, Vasanthi R; Connor, Agnieszka J; Zhou, Peihong; Gordon, Marion K; Laskin, Jeffrey D; Las ... | P30ES005022, R01ES004738, T32ES007148 | Respir Res (2002) | 12204102 | 2002 |
Activation of type II alveolar epithelial cells during acute endotoxemia. | Sunil, Vasanthi R; Connor, Agnieszka J; Guo, Yan; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738, T32ES007148 | Am J Physiol Lung Cell Mol Physiol (2002 Apr) | 11880315 | 2002 |
Acute endotoxemia prolongs the survival of rat lung neutrophils in response to 12-O-tetradecanoyl-ph ... | Sunil, Vasanthi R; Connor, Agnieszka J; Lavnikova, Natasha; Gardner, Carol R; Laskin, Jeffrey D ... | P30ES005022, R01ES004738, T32ES007148 | J Cell Physiol (2002 Mar) | 11857454 | 2002 |
Deficiency in inducible nitric oxide synthase protects mice from ozone-induced lung inflammation and ... | Fakhrzadeh, Ladan; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (2002 Apr) | 11919077 | 2002 |
Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induc ... | Chiu, Hawjyh; Brittingham, Jennie A; Laskin, Debra L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2002 Jun 1) | 12051994 | 2002 |
Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells. | Billack, Blase; Heck, Diane E; Mariano, Thomas M; Gardner, Carol R; Sur, Runa; Laskin, Debra L ... | P30ES005022, R01ES004738 | Am J Physiol Cell Physiol (2002 Oct) | 12225989 | 2002 |
Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential r ... | Gardner, Carol R; Laskin, Jeffrey D; Dambach, Donna M; Sacco, Michael; Durham, Stephen K; Bruno ... | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2002 Oct 1) | 12392966 | 2002 |
Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotox ... | Ahmad, Nosheen; Chen, Li C; Gordon, Marion A; Laskin, Jeffrey D; Laskin, Debra L | P30ES005022, R01ES004738 | J Leukoc Biol (2002 Jun) | 12050186 | 2002 |
Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in t ... | Dambach, Donna M; Watson, Linda M; Gray, Kevin R; Durham, Stephen K; Laskin, Debra L | P30ES005022, R01ES004738 | Hepatology (2002 May) | 11981759 | 2002 |
Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozo ... | Laskin, Debra L; Fakhrzadeh, Ladan; Heck, Diane E; Gerecke, Donald; Laskin, Jeffrey D | P30ES005022, R01ES004738 | Mol Cell Biochem (2002 May-Jun) | 12162464 | 2002 |
Functional heterogeneity in liver and lung macrophages. | Laskin, D L; Weinberger, B; Laskin, J D | R01ES004738 | J Leukoc Biol (2001 Aug) | 11493607 | 2001 |
Mechanisms underlying reduced responsiveness of neonatal neutrophils to distinct chemoattractants. | Weinberger, B; Laskin, D L; Mariano, T M; Sunil, V R; DeCoste, C J; Heck, D E; Gardner, C R; ... | P30ES005022, R01ES004738 | J Leukoc Biol (2001 Dec) | 11739560 | 2001 |
Nitric oxide and peroxynitrite in ozone-induced lung injury. | Laskin, D L; Fakhrzadeh, L; Laskin, J D | R01ES004738 | Adv Exp Med Biol (2001) | 11764933 | 2001 |
Prooxidant and antioxidant functions of nitric oxide in liver toxicity. | Laskin, J D; Heck, D E; Gardner, C R; Laskin, D L | P30ES005022, R01ES004738 | Antioxid Redox Signal (2001 Apr) | 11396480 | 2001 |
Role of macrophages and inflammatory mediators in chemically induced toxicity. | Laskin, D L; Laskin, J D | P30ES005022, R01ES004738 | Toxicology (2001 Mar 07) | 11246131 | 2001 |
The toxicology of inhaled nitric oxide. | Weinberger, B; Laskin, D L; Heck, D E; Laskin, J D | R01ES004738 | Toxicol Sci (2001 Jan) | 11134540 | 2001 |
Tissue injury following inhalation of fine particulate matter and hydrogen peroxide is associated wi ... | Morio, L A; Hooper, K A; Brittingham, J; Li, T H; Gordon, R E; Turpin, B J; Laskin, D L | P30ES005022, R01ES004738 | Toxicol Appl Pharmacol (2001 Dec 15) | 11749118 | 2001 |
Functional heterogeneity of rat hepatic and alveolar macrophages: effects of chronic ethanol adminis ... | Morio, L A; Chiu, H; Sprowles, K A; Laskin, D L | R01ES004738 | J Leukoc Biol (2000 Nov) | 11073098 | 2000 |
Distinct inflammatory responses of adherent vascular lung neutrophils to pulmonary irritants. | Lavnikova, N; Prokhorova, S; Lakhotia, A V; Gordon, R; Laskin, D L | P30ES005022, R01ES004738 | J Inflamm (1998) | 9656142 | 1998 |
Increased nitric oxide synthase in the lung after ozone inhalation is associated with activation of ... | Laskin, D L; Sunil, V; Guo, Y; Heck, D E; Laskin, J D | P30ES005022, R01ES004738 | Environ Health Perspect (1998 Oct) | 9788894 | 1998 |
Inhaled nitric oxide primes lung macrophages to produce reactive oxygen and nitrogen intermediates. | Weinberger, B; Fakhrzadeh, L; Heck, D E; Laskin, J D; Gardner, C R; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Crit Care Med (1998 Sep) | 9731028 | 1998 |
Role of inflammatory cytokines and nitric oxide in hepatic and pulmonary toxicity. | Laskin, D L; Heck, D E; Laskin, J D | R01ES004738 | Toxicol Lett (1998 Dec 28) | 10022268 | 1998 |
Macrophage and interleukin-1 induced nitric oxide production and cytostasis in hamster tumor cells v ... | Lavnikova, N; Burdelya, L; Lakhotia, A; Patel, N; Prokhorova, S; Laskin, D L | P30ES005022, R01ES004738 | J Leukoc Biol (1997 Apr) | 9103232 | 1997 |
Cytostasis is required for IL-1 induced nitric oxide production in transformed hamster fibroblasts. | Lavnikova, N; Lakhotia, A; Patel, N; Prokhorova, S; Laskin, D L | P30ES005022, R01ES004738 | J Cell Physiol (1996 Dec) | 8952702 | 1996 |
Inhibition of ozone-induced nitric oxide synthase expression in the lung by endotoxin. | Pendino, K J; Gardner, C R; Shuler, R L; Laskin, J D; Durham, S K; Barton, D S; Ohnishi, S T; ... | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1996 Jun) | 8652180 | 1996 |
Mechanisms regulating macrophage-induced nitric oxide production by spontaneously transformed hamste ... | Lavnikova, N; Prokhorova, S; Burdelia, L; Lakhotia, A; Laskin, D L | P30ES005022, R01ES004738 | J Leukoc Biol (1996 Oct) | 8864131 | 1996 |
Role of nitric oxide in hematosuppression and benzene-induced toxicity. | Laskin, D L; Heck, D E; Punjabi, C J; Laskin, J D | R01ES004738 | Environ Health Perspect (1996 Dec) | 9118907 | 1996 |
Stimulation of nitric oxide production in rat lung lavage cells by anti-Mac-1beta antibody: effects ... | Pendino, K J; Gardner, C R; Quinones, S; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1996 Apr) | 8600936 | 1996 |
Hepatic nitric oxide production following acute endotoxemia in rats is mediated by increased inducib ... | Laskin, D L; Rodriguez del Valle, M; Heck, D E; Hwang, S M; Ohnishi, S T; Durham, S K; Goller, ... | P30ES005022, R01ES004738 | Hepatology (1995 Jul) | 7541386 | 1995 |
Inhibition of macrophages with gadolinium chloride abrogates ozone-induced pulmonary injury and infl ... | Pendino, K J; Meidhof, T M; Heck, D E; Laskin, J D; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1995 Aug) | 7542894 | 1995 |
Macrophages and inflammatory mediators in tissue injury. | Laskin, D L; Pendino, K J | P30ES005022, R01ES004738 | Annu Rev Pharmacol Toxicol (1995) | 7598511 | 1995 |
Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia. | Schuller-Levis, G B; Gordon, R E; Park, E; Pendino, K J; Laskin, D L | R01ES004738 | Exp Lung Res (1995 Nov-Dec) | 8591791 | 1995 |
Unique patterns of regulation of nitric oxide production in fibroblasts. | Lavnikova, N; Laskin, D L | P30ES005022, R01ES004738 | J Leukoc Biol (1995 Oct) | 7561522 | 1995 |
Activation of alveolar macrophages by native and synthetic collagen-like polypeptides. | Laskin, D L; Soltys, R A; Berg, R A; Riley, D J | R01ES004738 | Am J Respir Cell Mol Biol (1994 Jan) | 8292381 | 1994 |
Alterations in expression of p56lck during myeloid differentiation of LSTRA cells. | Garcia-Welsh, A; Laskin, D L; Molloy, C J; Laskin, J D | P30ES005022, R01ES004738 | Cell Growth Differ (1994 Nov) | 7531490 | 1994 |
Cellular depletion of p56lck during thymocyte apoptosis. | Garcia-Welsh, A; Laskin, D L; Shuler, R L; Laskin, J D | P30ES005022, R01ES004738 | J Leukoc Biol (1994 Oct) | 7930951 | 1994 |
Enhanced phagocytosis, chemotaxis, and production of reactive oxygen intermediates by interstitial l ... | Wizemann, T M; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1994 Sep) | 8086172 | 1994 |
Enhanced production of interleukin-1, tumor necrosis factor-alpha, and fibronectin by rat lung phago ... | Pendino, K J; Shuler, R L; Laskin, J D; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1994 Sep) | 8086166 | 1994 |
Enhanced production of nitric oxide by bone marrow cells and increased sensitivity to macrophage col ... | Punjabi, C J; Laskin, J D; Hwang, S M; MacEachern, L; Laskin, D L | R01ES004738 | Blood (1994 Jun 01) | 8193360 | 1994 |
Functional characterization of interstitial macrophages and subpopulations of alveolar macrophages f ... | Prokhorova, S; Lavnikova, N; Laskin, D L | P30ES005022, R01ES004738 | J Leukoc Biol (1994 Feb) | 8301209 | 1994 |
Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in ... | Hwang, S M; Lopez, C A; Heck, D E; Gardner, C R; Laskin, D L; Laskin, J D; Denhardt, D T | R01ES004738 | J Biol Chem (1994 Jan 07) | 7506262 | 1994 |
Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. | Wizemann, T M; Gardner, C R; Laskin, J D; Quinones, S; Durham, S K; Goller, N L; Ohnishi, S T ... | P30ES005022, R01ES004738 | J Leukoc Biol (1994 Dec) | 7527832 | 1994 |
Production of nitric oxide by differentiated LSTRA cells is associated with expression of macrophage ... | Garcia-Welsh, A; Laskin, D L; Hwang, S M; Denhardt, D T; Laskin, J D | P30ES005022, R01ES004738 | J Leukoc Biol (1994 Oct) | 7523558 | 1994 |
Pulmonary and hepatic effects of inhaled ozone in rats. | Laskin, D L; Pendino, K J; Punjabi, C J; Rodriguez del Valle, M; Laskin, J D | P30ES005022, R01ES004738 | Environ Health Perspect (1994 Dec) | 7705308 | 1994 |
A single exogenous stimulus activates resident rat macrophages for nitric oxide production and tumor ... | Lavnikova, N; Drapier, J C; Laskin, D L | R01ES004738 | J Leukoc Biol (1993 Oct) | 8409754 | 1993 |
Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irri ... | Pendino, K J; Laskin, J D; Shuler, R L; Punjabi, C J; Laskin, D L | P30ES005022, R01ES004738, T32ES007148 | J Immunol (1993 Dec 15) | 7505023 | 1993 |
Induction of functionally active platelet-activating factor receptors in rat alveolar macrophages. | Pendino, K J; Gardner, C R; Laskin, J D; Laskin, D L | P30ES005022, R01ES004738, T32ES007148 | J Biol Chem (1993 Sep 15) | 8396125 | 1993 |
Isolation and partial characterization of subpopulations of alveolar macrophages, granulocytes, and ... | Lavnikova, N; Prokhorova, S; Helyar, L; Laskin, D L | P30ES005022, R01ES004738 | Am J Respir Cell Mol Biol (1993 Apr) | 8476632 | 1993 |
Platelet-activating factor-induced calcium mobilization and oxidative metabolism in hepatic macropha ... | Gardner, C R; Laskin, J D; Laskin, D L | R01ES004738 | J Leukoc Biol (1993 Feb) | 8383168 | 1993 |
Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferat ... | Punjabi, C J; Laskin, D L; Heck, D E; Laskin, J D | P30ES005022, R01ES004738 | J Immunol (1992 Sep 15) | 1517578 | 1992 |
Activation of neutrophils by factors released from alveolar macrophages stimulated with collagen-lik ... | Laskin, D L; Soltys, R A; Berg, R A; Riley, D J | R01ES004738 | Am J Respir Cell Mol Biol (1990 May) | 2160256 | 1990 |