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Who We Fund: Publication Detail

Project Title: NEUROINFLAMMATION AND DEVELOPMENTAL VULNERABILITY TO MANGANESE TOXICITY
PI: Tjalkens, Ronald
Institution: Colorado State University
Grant Number: R01ES021656

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Viewing 34 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
Microglia-specific knock-out of NF-κB/IKK2 increases the accumulation of misfolded α-synuclein throu ...   Rocha, Savannah M; Kirkley, Kelly S; Chatterjee, Debotri; Aboellail, Tawfik A; Smeyne, Richard ... R01ES021656, R01ES030937, R35ES035043 Glia (2023 Sep) 37199240 Exiting the NIEHS site 2023 
Structure-Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites ...   Paranjape, Neha; Dean, Laura E; Martinez, Andres; Tjalkens, Ronald B; Lehmler, Hans-Joachim; Do ... P30ES005605, P42ES013661, R01ES021656, R01ES029035 Chem Res Toxicol (2023 Jun 19) 37279407 Exiting the NIEHS site 2023 
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflamm ...   Rocha, Savannah M; Fagre, Anna C; Latham, Amanda S; Cummings, Jason E; Aboellail, Tawfik A; Rei ... R01ES021656, R01ES030937 Front Immunol (2022) 35250984 Exiting the NIEHS site 2022 
Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to ...   Rocha, Savannah M; Bantle, Collin M; Aboellail, Tawfik; Chatterjee, Debotri; Smeyne, Richard J; ... R01ES021656 Neurobiol Dis (2022 Jun 01) 35257879 Exiting the NIEHS site 2022 
A Low-Cost, Autonomous Gait Detection and Estimation System for Analyzing Gait Impairments in Mice.   Damale, Pranav U; Chong, Edwin K P; Hammond, Sean L; Tjalkens, Ronald B R01ES021656, R01ES030937 J Healthc Eng (2021) 34804462 Exiting the NIEHS site 2021 
Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss fol ...   Bantle, Collin M; Rocha, Savannah M; French, C Tenley; Phillips, Aaron T; Tran, Kevin; Olson, ... R01ES021656, R01ES030937 Exp Neurol (2021 Dec) 34454938 Exiting the NIEHS site 2021 
Can We Panelize Seizure?   Roberts, Ruth; Authier, Simon; Mellon, R Daniel; Morton, Michael; Suzuki, Ikuro; Tjalkens, Ron ... R01ES021656 Toxicol Sci (2021 01 06) 33165543 Exiting the NIEHS site 2021 
A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Sev ...   Fagre, Anna C; Manhard, John; Adams, Rachel; Eckley, Miles; Zhan, Shijun; Lewis, Juliette; Roc ... R01ES021656, R01ES030937 Front Immunol (2020) 33391285 Exiting the NIEHS site 2020 
NF-κB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential ...   Hammond, Sean L; Bantle, Collin M; Popichak, Katriana A; Wright, Katie A; Thompson, Delaney; Fo ... R01ES021656 Toxicol Sci (2020 10 01) 32692843 Exiting the NIEHS site 2020 
Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas.   Karki, Keshav; Li, Xi; Jin, Un-Ho; Mohankumar, Kumaravel; Zarei, Mahsa; Michelhaugh, Sharon K; ... P30ES029067, R01ES021656, R01ES030937, T32ES026568 J Neurooncol (2020 Jan) 31754919 Exiting the NIEHS site 2020 
Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry o ...   Malmlov, Ashley; Bantle, Collin; Aboellail, Tawfik; Wagner, Kaitlyn; Campbell, Corey L; Eckley, ... R01ES021656 PLoS Negl Trop Dis (2019 Feb) 30716104 Exiting the NIEHS site 2019 
Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss ...   Kirkley, Kelly S; Popichak, Katriana A; Hammond, Sean L; Davies, Cecilia; Hunt, Lindsay; Tjalke ... R01ES021656 Neurobiol Dis (2019 07) 30818064 Exiting the NIEHS site 2019 
Structure-dependent activation of gene expression by bis-indole and quinoline-derived activators of ...   Li, Xi; Tjalkens, Ronald B; Shrestha, Rupesh; Safe, Stephen P30ES029067, R01ES021656, T32ES026568 Chem Biol Drug Des (2019 10) 31102570 Exiting the NIEHS site 2019 
A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor ...   Afzali, Maryam F; Popichak, Katriana A; Burton, Lindsey H; Klochak, Anna L; Wilson, William J; ... R01ES021656 Mol Immunol (2018 09) 29870816 Exiting the NIEHS site 2018 
Compensatory Expression of Nur77 and Nurr1 Regulates NF-κB-Dependent Inflammatory Signaling in Astro ...   Popichak, Katriana A; Hammond, Sean L; Moreno, Julie A; Afzali, Maryam F; Backos, Donald S; Sla ... R01ES021656 Mol Pharmacol (2018 10) 30111648 Exiting the NIEHS site 2018 
Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese.   Popichak, Katriana A; Afzali, Maryam F; Kirkley, Kelly S; Tjalkens, Ronald B R01ES021656 J Neuroinflammation (2018 Nov 21) 30463564 Exiting the NIEHS site 2018 
The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Ne ...   Hammond, Sean L; Popichak, Katriana A; Li, Xi; Hunt, Lindsay G; Richman, Evan H; Damale, Prana ... R01ES021656 J Pharmacol Exp Ther (2018 Jun) 29626009 Exiting the NIEHS site 2018 
Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intrac ...   Hammond, Sean L; Leek, Ashley N; Richman, Evan H; Tjalkens, Ronald B R01ES021656 PLoS One (2017) 29244806 Exiting the NIEHS site 2017 
Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity.   Tjalkens, Ronald B; Popichak, Katriana A; Kirkley, Kelly A R01ES021656 Adv Neurobiol (2017) 28889267 Exiting the NIEHS site 2017 
Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity.   Kirkley, Kelly S; Popichak, Katriana A; Afzali, Maryam F; Legare, Marie E; Tjalkens, Ronald B R01ES021656 J Neuroinflammation (2017 May 05) 28476157 Exiting the NIEHS site 2017 
Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of ...   Kirkley, Kelly S; Walton, Kelly D; Duncan, Colleen; Tjalkens, Ronald B R01ES021656 Comp Med (2017 Oct 01) 28935002 Exiting the NIEHS site 2017 
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous Syste ...   Phillips, Aaron T; Rico, Amber B; Stauft, Charles B; Hammond, Sean L; Aboellail, Tawfik A; Tjal ... R01ES021656 J Virol (2016 Jun 15) 27053560 Exiting the NIEHS site 2016 
Nuclear receptor 4A (NR4A) family - orphans no more.   Safe, Stephen; Jin, Un-Ho; Morpurgo, Benjamin; Abudayyeh, Ala; Singh, Mandip; Tjalkens, Ronald ... P30ES005022, R01ES021656 J Steroid Biochem Mol Biol (2016 Mar) 25917081 Exiting the NIEHS site 2016 
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect ...   Rico, Amber B; Phillips, Aaron T; Schountz, Tony; Jarvis, Donald L; Tjalkens, Ronald B; Powers, ... R01ES021656 Virology (2016 Dec) 27632563 Exiting the NIEHS site 2016 
A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hyd ...   Hammond, Sean L; Safe, Stephen; Tjalkens, Ronald B R01ES021656 Neurosci Lett (2015 Oct 21) 26383113 Exiting the NIEHS site 2015 
Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response el ...   Li, Wencheng; Liu, Jiao; Hammond, Sean L; Tjalkens, Ronald B; Saifudeen, Zubaida; Feng, Yumei R01ES021656 Am J Physiol Regul Integr Comp Physiol (2015 Jul 15) 25994957 Exiting the NIEHS site 2015 
Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glia ...   De Miranda, Briana R; Popichak, Katriana A; Hammond, Sean L; Miller, James A; Safe, Stephen; Tj ... R01ES021656 Toxicol Sci (2015 Feb) 25406165 Exiting the NIEHS site 2015 
Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water an ...   Schilz, Jodi R; Reddy, K J; Nair, Sreejayan; Johnson, Thomas E; Tjalkens, Ronald B; Krueger, K ... R01ES021656 J Vis Exp (2015 Jun 21) 26132311 Exiting the NIEHS site 2015 
The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expressio ...   De Miranda, Briana R; Popichak, Katriana A; Hammond, Sean L; Jorgensen, Bryce A; Phillips, Aaro ... R01ES021656 Mol Pharmacol (2015 Jun) 25858541 Exiting the NIEHS site 2015 
Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells.   Lee, Syng-Ook; Li, Xi; Hedrick, Erik; Jin, Un-Ho; Tjalkens, Ronald B; Backos, Donald S; Li, L ... R01ES021656 Mol Endocrinol (2014 Oct) 25099012 Exiting the NIEHS site 2014 
Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes.   Streifel, Karin M; Gonzales, Albert L; De Miranda, Briana; Mouneimne, Rola; Earley, Scott; Tjal ... R01ES021656 PLoS One (2014) 25365260 Exiting the NIEHS site 2014 
Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seiz ...   Miller, James A; Kirkley, Kelly A; Padmanabhan, Rachel; Liang, Li-Ping; Raol, Yogendra H; Patel ... R01ES021656 Neurotoxicology (2014 Sep) 24813937 Exiting the NIEHS site 2014 
Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 ...   Streifel, Karin M; Miller, James; Mouneimne, Rola; Tjalkens, Ronald B R01ES021656 Neurotoxicology (2013 Jan) 23131343 Exiting the NIEHS site 2013 
Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substit ...   De Miranda, Briana R; Miller, James A; Hansen, Ryan J; Lunghofer, Paul J; Safe, Stephen; Gustaf ... R01ES021656 J Pharmacol Exp Ther (2013 Apr) 23318470 Exiting the NIEHS site 2013 
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