Project Title: | PCB-MEDIATED DYSBIOSIS OF THE GUT MICROBIOME: A MISSING LINK IN PCB-MEDIATED NEURODEVELOPMENTAL DISORDERS? |
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PI: | Lehmler, Hans-Joachim |
Institution: | University Of Iowa |
Grant Number: | R01ES031098 |
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Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
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Disposition and Metabolomic Effects of 2,2',5,5'-Tetrachlorobiphenyl in Female Rats Following Intrap ... | Bullert, Amanda; Li, Xueshu; Zhang, Chunyun; Lee, Kendra; Pulliam, Casey F; Cagle, Brianna S; ... | P30ES005605, P42ES013661, R01ES014901, R01ES031098 | bioRxiv (2023 Aug 09) | 37609242 | 2023 |
Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intrap ... | Bullert, Amanda; Li, Xueshu; Chunyun, Zhang; Lee, Kendra; Pulliam, Casey F; Cagle, Brianna S; ... | P30ES005605, P42ES013661, R01ES014901, R01ES031098 | Environ Toxicol Pharmacol (2023 Sep) | 37572994 | 2023 |
Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2',3,5',6-Pentachlo ... | Li, Xueshu; Bullert, Amanda J; Han, Weiguo; Yang, Weizhu; Zhang, Qing-Yu; Ding, Xinxin; Lehmle ... | P30ES005605, P30ES006694, P42ES013661, R01ES014901, R01ES020867, R01ES031098 | Chem Res Toxicol (2023 Aug 21) | 37467352 | 2023 |
Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in hum ... | Kim, Sarah; Li, Hao; Jin, Yan; Armad, Jasmine; Gu, Haiwei; Mani, Sridhar; Cui, Julia Y | P30ES007033, R01ES030197, R01ES031098 | Toxicol Sci (2023 Jul 28) | 37267213 | 2023 |
Rebuttal to Correspondence on "Machine Learning-Assisted Identification and Quantification of Hydrox ... | Zhang, Chun-Yun; Li, Xueshu; Keil Stietz, Kimberly P; Sethi, Sunjay; Yang, Weizhu; Marek, Rach ... | P30ES005605, P30ES006694, P30ES023513, P42ES013661, R01ES014901, R01ES031098 | Environ Sci Technol (2023 Apr 18) | 37017328 | 2023 |
Effect of Chronic Cadmium Exposure on Brain and Liver Transporters and Drug-Metabolizing Enzymes in ... | Wang, Hao; Zhang, Liang; Xia, Zhengui; Cui, Julia Yue | P30ES007033, R01ES030197, R01ES031098 | Drug Metab Dispos (2022 Oct) | 35878927 | 2022 |
Machine Learning-Assisted Identification and Quantification of Hydroxylated Metabolites of Polychlor ... | Zhang, Chun-Yun; Li, Xueshu; Keil Stietz, Kimberly P; Sethi, Sunjay; Yang, Weizhu; Marek, Rach ... | P30ES005605, P30ES023513, P42ES013661, R01ES014901, R01ES031098 | Environ Sci Technol (2022 Sep 20) | 36047920 | 2022 |
Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Meta ... | Zhang, Chun-Yun; Li, Xueshu; Flor, Susanne; Ruiz, Patricia; Kruve, Anneli; Ludewig, Gabriele; ... | P30ES005605, P42ES013661, R01ES014901, R01ES031098 | Environ Sci Technol (2022 Sep 06) | 35994059 | 2022 |
Perfluorinated Carboxylic Acids with Increasing Carbon Chain Lengths Upregulate Amino Acid Transport ... | Lim, Joe Jongpyo; Suh, Youjun; Faustman, Elaine M; Cui, Julia Yue | P30ES007033, R01ES030197, R01ES031098, T32ES007032 | Drug Metab Dispos (2022 Oct) | 34857530 | 2022 |
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. | Dutta, Moumita; Lim, Joe Jongpyo; Cui, Julia Yue | P30ES005605, R01ES030197, R01ES031098 | Drug Metab Dispos (2022 Apr) | 34862253 | 2022 |
The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. | Li, Xueshu; Lim, Joe Jongpyo; Wang, Kai; Prasad, Bhagwat; Bhatt, Deepak K; Cui, Julia Yue; Leh ... | P30ES005605, P30ES007033, P42ES013661, R01ES014901, R01ES031098, T32ES007032 | Environ Toxicol Pharmacol (2022 May) | 35331926 | 2022 |
Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and C ... | Little, Mallory; Dutta, Moumita; Li, Hao; Matson, Adam; Shi, Xiaojian; Mascarinas, Gabby; Moll ... | P30ES007033, R01ES031098, R25ES025503 | Acta Pharm Sin B (2022 Feb) | 35256948 | 2022 |
Cadmium exposure modulates the gut-liver axis in an Alzheimer's disease mouse model. | Zhang, Angela; Matsushita, Megumi; Zhang, Liang; Wang, Hao; Shi, Xiaojian; Gu, Haiwei; Xia, Z ... | P30ES007033, R01ES030197, R01ES031098, T32ES007032, T32ES015459 | Commun Biol (2021 Dec 15) | 34912029 | 2021 |
Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metab ... | Zhang, Chun-Yun; Flor, Susanne; Ruiz, Patricia; Ludewig, Gabriele; Lehmler, Hans-Joachim | P30ES005605, P42ES013661, R01ES014901, R01ES031098 | Environ Sci Technol (2021 07 06) | 34125531 | 2021 |
Disposition of PCB 11 in Mice Following Acute Oral Exposure. | Zhang, Chun-Yun; Klocke, Carolyn R; Lein, Pamela J; Lehmler, Hans-Joachim | P30ES005605, P42ES013661, R01ES014901, R01ES029213, R01ES029213, R01ES031098 | Chem Res Toxicol (2021 04 19) | 33734669 | 2021 |
Neonatal Exposure to BPA, BDE-99, and PCB Produces Persistent Changes in Hepatic Transcriptome Assoc ... | Lim, Joe Jongpyo; Dutta, Moumita; Dempsey, Joseph L; Lehmler, Hans-Joachim; MacDonald, James; B ... | P30ES005605, P30ES007033, P30ES030285, R01ES030197, R01ES031098, T32ES007032 | Toxicol Sci (2021 Oct 27) | 34453844 | 2021 |
Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles ... | Li, Xueshu; Liu, Yanna; Martin, Jonathan W; Cui, Julia Yue; Lehmler, Hans-Joachim | P30ES005605, P30ES007033, P42ES013661, R01ES014901, R01ES030197, R01ES031098 | Environ Pollut (2021 Jan 01) | 33032095 | 2021 |
Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflamm ... | Kim, Sarah; Choi, Sora; Dutta, Moumita; Asubonteng, Jeffrey O; Polunas, Marianne; Goedken, Mic ... | P30ES005605, P30ES007033, R01ES030197, R01ES031098 | Biochem Pharmacol (2021 Nov) | 34303710 | 2021 |
RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine. | Fu, Zidong Donna; Selwyn, Felcy Pavithra; Cui, Julia Yue; Klaassen, Curtis D | P30ES007033, R01ES031098 | Toxicol Appl Pharmacol (2021 12 15) | 34715074 | 2021 |
Fatty liver and impaired hepatic metabolism alter the congener-specific distribution of polychlorina ... | Li, Xueshu; Zhang, Chunyun; Wang, Kai; Lehmler, Hans-Joachim | P30ES005605, P42ES013661, R01ES014901, R01ES031098 | Environ Pollut (2020 Nov) | 32712482 | 2020 |
Gut Microbiome Critically Impacts PCB-induced Changes in Metabolic Fingerprints and the Hepatic Tran ... | Lim, Joe Jongpyo; Li, Xueshu; Lehmler, Hans-Joachim; Wang, Dongfang; Gu, Haiwei; Cui, Julia Yu ... | P30ES005605, P30ES007033, P42ES013661, R01ES030197, R01ES031098, T32ES007032 | Toxicol Sci (2020 09 01) | 32544245 | 2020 |