| Project Title: | PROTEIN KINASE SIGNALING IN THE GENOTOXIC STRESS RESPONSE |
|---|---|
| PI: | Yaffe, Michael B |
| Institution: | Massachusetts Institute Of Technology |
| Grant Number: | R35ES028374 |
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Viewing 41 publications
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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Activation of GPR3-β-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obes ... | Dong, Ting; Hu, Guangan; Fan, Zhongqi; Wang, Huirui; Gao, Yinghui; Wang, Sisi; Xu, Hao; Yaffe ... | R35ES028374 | Nat Commun (2024 Jan 27) |
38280848
|
2024 |
| The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombinat ... | van de Kooij, Bert; van der Wal, Fenna J; Rother, Magdalena B; Wiegant, Wouter W; Creixell, Pau ... | R35ES028374 | Nat Commun (2024 Aug 16) |
39152113
|
2024 |
| The intrinsic substrate specificity of the human tyrosine kinome. | Yaron-Barir, Tomer M; Joughin, Brian A; Huntsman, Emily M; Kerelsky, Alexander; Cizin, Daniel M ... | R35ES028374 | Nature (2024 May) |
38720073
|
2024 |
| An atlas of substrate specificities for the human serine/threonine kinome. | Johnson, Jared L; Yaron, Tomer M; Huntsman, Emily M; Kerelsky, Alexander; Song, Junho; Regev, ... | R35ES028374 | Nature (2023 Jan) |
36631611
|
2023 |
| An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types. | Chen, Jung-Kuei; Merrick, Karl A; Kong, Yi Wen; Izrael-Tomasevic, Anita; Eng, George; Handly, ... | R35ES028374 | bioRxiv (2023 Apr 29) |
37162991
|
2023 |
| Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA dama ... | Netterfield, Tatiana S; Ostheimer, Gerard J; Tentner, Andrea R; Joughin, Brian A; Dakoyannis, A ... | R35ES028374 | Cell Syst (2023 Jul 19) |
37473730
|
2023 |
| Early Immune Changes Support Signet Ring Cell Dormancy in CDH1-Driven Hereditary Diffuse Gastric Car ... | Green, Benjamin L; Gamble, Lauren A; Diggs, Laurence P; Nousome, Darryl; Patterson, Jesse C; Jo ... | R35ES028374 | Mol Cancer Res (2023 Dec 01) |
37707375
|
2023 |
| MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA da ... | Stehn, Justine R; Floyd, Scott R; Wilker, Erik W; Reinhardt, H Christian; Clarke, Scott M; Huan ... | R35ES028374 | Front Mol Biosci (2023) |
37091863
|
2023 |
| Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density ... | Goretti Riça, Ingred; Joughin, Brian A; Teke, Martha E; Emmons, Tiffany R; Griffith, Alec M; Ca ... | R35ES028374 | J Trauma Acute Care Surg (2023 Feb 01) |
36694330
|
2023 |
| Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells. | Segal, Brahm H; Giridharan, Thejaswini; Suzuki, Sora; Khan, Anm Nazmul H; Zsiros, Emese; Emmons ... | R35ES028374 | Immunol Rev (2023 Mar) |
36527200
|
2023 |
| Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate O ... | Patterson, Jesse C; Varkaris, Andreas; Croucher, Peter J P; Ridinger, Maya; Dalrymple, Susan; N ... | R35ES028374 | Cancer Res (2023 Jan 18) |
36413141
|
2023 |
| The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombinat ... | van de Kooij, Bert; van der Wal, Fenna J; Rother, Magdalena B; Creixell, Pau; Stout, Merula; Wi ... | R35ES028374 | bioRxiv (2023 Sep 06) |
37732274
|
2023 |
| A haem-sequestering plant peptide promotes iron uptake in symbiotic bacteria. | Sankari, Siva; Babu, Vignesh M P; Bian, Ke; Alhhazmi, Areej; Andorfer, Mary C; Avalos, Dante M ... | R35ES028374 | Nat Microbiol (2022 Sep) |
35953657
|
2022 |
| Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer ... | Sriram, Ganapathy; Emmons, Tiffany R; Milling, Lauren E; Irvine, Darrell J; Yaffe, Michael B | R35ES028374 | Mol Cell Oncol (2022) |
35402699
|
2022 |
| Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing a ... | van de Kooij, Bert; Kruswick, Alex; van Attikum, Haico; Yaffe, Michael B | R35ES028374 | Nat Commun (2022 Sep 08) |
36075911
|
2022 |
| Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1. | Ryu, SeongShick; Park, Jung-Eun; Ham, Young Jin; Lim, Daniel C; Kwiatkowski, Nicholas P; Kim, ... | R35ES028374 | J Med Chem (2022 Feb 10) |
35029981
|
2022 |
| The injury response to DNA damage in live tumor cells promotes antitumor immunity. | Sriram, Ganapathy; Milling, Lauren E; Chen, Jung-Kuei; Kong, Yi Wen; Joughin, Brian A; Abraham, ... | R35ES028374 | Sci Signal (2021 Oct 19) |
34665642
|
2021 |
| Are redox changes a critical switch for mitotic progression? | Lim, Daniel C; Joukov, Vladimir; Yaffe, Michael B | R35ES028374 | Mol Cell Oncol (2020 Oct 23) |
33235921
|
2020 |
| BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision e ... | Lam, Fred C; Kong, Yi Wen; Huang, Qiuying; Vu Han, Tu-Lan; Maffa, Amanda D; Kasper, Ekkehard M ... | R35ES028374 | Nat Commun (2020 Aug 14) |
32796829
|
2020 |
| Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide exc ... | Kong, Yi Wen; Dreaden, Erik C; Morandell, Sandra; Zhou, Wen; Dhara, Sanjeev S; Sriram, Ganapat ... | R35ES028374 | Nat Commun (2020 08 17) |
32807787
|
2020 |
| Inducing DNA damage through R-loops to kill cancer cells. | Lam, Fred C; Kong, Yi Wen; Yaffe, Michael B | R35ES028374 | Mol Cell Oncol (2020 Nov 20) |
33553604
|
2020 |
| MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model o ... | Suarez-Lopez, Lucia; Kong, Yi Wen; Sriram, Ganapathy; Patterson, Jesse C; Rosenberg, Samantha; ... | R35ES028374 | Front Immunol (2020) |
33708191
|
2020 |
| Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis d ... | Kang, Joon Ho; Katsikis, Georgios; Li, Zhaoqi; Sapp, Kiera M; Stockslager, Max A; Lim, Daniel; ... | R35ES028374 | Nat Commun (2020 10 05) |
33020492
|
2020 |
| Redox priming promotes Aurora A activation during mitosis. | Lim, Daniel C; Joukov, Vladimir; Rettenmaier, T Justin; Kumagai, Akiko; Dunphy, William G; Well ... | R35ES028374 | Sci Signal (2020 07 21) |
32694171
|
2020 |
| Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulat ... | Krismer, Konstantin; Bird, Molly A; Varmeh, Shohreh; Handly, Erika D; Gattinger, Anna; Bernwink ... | R35ES028374 | Cell Rep (2020 Aug 25) |
32846122
|
2020 |
| Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggres ... | Rohani, Nazanin; Hao, Liangliang; Alexis, Maria S; Joughin, Brian A; Krismer, Konstantin; Moufa ... | R35ES028374 | Cancer Res (2019 Apr 15) |
30755444
|
2019 |
| Comprehensive profiling of the STE20 kinase family defines features essential for selective substrat ... | Miller, Chad J; Lou, Hua Jane; Simpson, Craig; van de Kooij, Bert; Ha, Byung Hak; Fisher, Oria ... | R35ES028374 | PLoS Biol (2019 Mar) |
30897078
|
2019 |
| Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling o ... | van de Kooij, Bert; Creixell, Pau; van Vlimmeren, Anne; Joughin, Brian A; Miller, Chad J; Haide ... | R35ES028374 | Elife (2019 05 24) |
31124786
|
2019 |
| Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Tr ... | Kasikara, Canan; Davra, Viralkumar; Calianese, David; Geng, Ke; Spires, Thomas E; Quigley, Mic ... | R35ES028374 | Cancer Res (2019 05 15) |
30877108
|
2019 |
| ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are ... | Patterson, Jesse C; Joughin, Brian A; van de Kooij, Bert; Lim, Daniel C; Lauffenburger, Douglas ... | R35ES028374 | Cell Syst (2019 02 27) |
30797774
|
2019 |
| Substrate-based kinase activity inference identifies MK2 as driver of colitis. | Strasser, Samantha Dale; Ghazi, Phaedra C; Starchenko, Alina; Boukhali, Myriam; Edwards, Amanda ... | R35ES028374 | Integr Biol (Camb) (2019 11 26) |
31617572
|
2019 |
| VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. | Patterson, Jesse C; Joughin, Brian A; Prota, Andrea E; Mühlethaler, Tobias; Jonas, Oliver H; Wh ... | R35ES028374 | Cell Syst (2019 07 24) |
31302152
|
2019 |
| Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targe ... | Lam, Fred C; Morton, Stephen W; Wyckoff, Jeffrey; Vu Han, Tu-Lan; Hwang, Mun Kyung; Maffa, Ama ... | R35ES028374 | Nat Commun (2018 May 18) |
29777137
|
2018 |
| Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. | Creixell, Pau; Pandey, Jai P; Palmeri, Antonio; Bhattacharyya, Moitrayee; Creixell, Marc; Ranga ... | R35ES028374 | Cell Syst (2018 10 24) |
30243563
|
2018 |
| Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inh ... | Hymel, David; Grant, Robert A; Tsuji, Kohei; Yaffe, Michael B; Burke Jr, Terrence R | R35ES028374 | Bioorg Med Chem Lett (2018 Oct 15) |
30174151
|
2018 |
| MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. | Suarez-Lopez, Lucia; Sriram, Ganapathy; Kong, Yi Wen; Morandell, Sandra; Merrick, Karl A; Herna ... | R35ES028374 | Proc Natl Acad Sci U S A (2018 05 01) |
29666270
|
2018 |
| RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors. | Dreaden, Erik C; Kong, Yi Wen; Quadir, Mohiuddin A; Correa, Santiago; Suárez-López, Lucia; Barb ... | R35ES028374 | Bioeng Transl Med (2018 Jan) |
29376131
|
2018 |
| Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploita ... | Braun, Christian J; Stanciu, Monica; Boutz, Paul L; Patterson, Jesse C; Calligaris, David; Higu ... | R35ES028374 | Cancer Cell (2017 10 09) |
28966034
|
2017 |
| A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. | Rameseder, Jonathan; Krismer, Konstantin; Dayma, Yogesh; Ehrenberger, Tobias; Hwang, Mun Kyung; ... | R35ES028374 | J Biomol Screen (2015 Sep) |
25918037
|
2015 |
| A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p5 ... | Cannell, Ian G; Merrick, Karl A; Morandell, Sandra; Zhu, Chang-Qi; Braun, Christian J; Grant, ... | R35ES028374 | Cancer Cell (2015 Nov 09) |
26602816
|
2015 |
| Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macro ... | Qian, Wen-Jian; Park, Jung-Eun; Grant, Robert; Lai, Christopher C; Kelley, James A; Yaffe, Mic ... | R35ES028374 | Biopolymers (2015 Nov) |
26152807
|
2015 |