Title: Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.

Authors: Liu, Pengyuan; Vikis, Haris G; Wang, Daolong; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; Yang, Ping; de Andrade, Mariza; Petersen, Gloria M; Wiest, Jonathan S; Fain, Pamela R; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Wu, Xifeng; Spitz, Margaret R; Eisen, Timothy; Houlston, Richard S; Amos, Christopher I; Anderson, Marshall W; You, Ming

Published In J Natl Cancer Inst, (2008 Sep 17)

Abstract: Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

PubMed ID: 18780872

MeSH Terms: Case-Control Studies; Chromosomes, Human, Pair 15*/genetics; Confounding Factors (Epidemiology); DNA, Neoplasm/analysis*; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms/genetics*; Polymorphism, Single Nucleotide*; Research Design; Sequence Analysis, DNA; Smoking/adverse effects