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Title: Acute effects of pyrethroids on serotonin release in the striatum of awake rats: an in vivo microdialysis study.

Authors: Hossain, Muhammad M; Suzuki, Tadahiko; Richardson, Jason R; Kobayashi, Haruo

Published In J Biochem Mol Toxicol, (2013 Feb)

Abstract: The present study examined the acute neurotoxic effects of three different pyrethroids, allethrin, cyhalothrin, and deltamethrin on the release of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the striatum of conscious rats using microdialysis. Allethrin 10 mg/kg reduced extracellular levels of 5-HT to 46%, whereas 20 and 60 mg/kg increased the release to 177% and 243% of baseline, respectively. Cyhalothrin increased 5-HT release to 145-204% and deltamethrin decreased to 58-32% of baseline in a dose-dependent manner. None of the pyrethroids tested altered extracellular levels of 5-HIAA. Local infusion of the voltage-gated sodium channel antagonist tetrodotoxin (TTX) into striatum completely prevented the effects of allethrin, cyhalothrin, and deltamethrin (10 and 20 mg/kg) on 5-HT release. The effect of deltamethrin at 60 mg/kg was completely abolished by striatal infusion of nimodipine (L-type Caýýýýýý channel antagonist) with TTX. These findings suggest that pyrethroids disrupt the serotonergic neurotransmission in striatum in a dose-related manner with Naýýý and Caýýýýý channel-dependent mechanisms.

PubMed ID: 23132818 Exiting the NIEHS site

MeSH Terms: Animals; Corpus Striatum/metabolism*; Corpus Striatum/pathology; Dose-Response Relationship, Drug; Insecticides/toxicity*; Male; Microdialysis; Pyrethrins/toxicity*; Rats; Rats, Sprague-Dawley; Serotonin/metabolism*; Sodium Channel Blockers/pharmacology; Tetrodotoxin/pharmacology; Wakefulness/drug effects*

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