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Title: Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys.

Authors: Lam, Thuy; Williams, Paige L; Burns, Jane S; Sergeyev, Oleg; Korrick, Susan A; Lee, Mary M; Birnbaum, Linda S; Revich, Boris; Altshul, Larisa M; Patterson Jr, Donald G; Turner, Wayman E; Hauser, Russ

Published In Environ Health Perspect, (2013 Nov-Dec)

Abstract: Few studies have evaluated predictors of childhood exposure to organochlorine pesticides (OCPs), a class of lipophilic persistent chemicals.Our goal was to identify predictors of serum OCP concentrations-hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p´-DDE)-among boys in Chapaevsk, Russia.Between 2003 and 2005, 499 boys 8-9 years of age were recruited in a prospective cohort. The initial study visit included a physical examination; blood collection; health, lifestyle, and food-frequency questionnaires; and determination of residential distance from a local factory complex that produced HCB and β-HCH. Fasting serum samples were analyzed for OCPs at the U.S. Centers for Disease Control and Prevention. General linear regression models were used to identify predictors of the boys' serum HCB, β-HCH, and p,p´-DDE concentrations.Among 355 boys with OCP measurements, median serum HCB, β-HCH, and p,p´-DDE concentrations were 158, 167, and 284 ng/g lipid, respectively. Lower body mass index, longer breastfeeding duration, and local dairy consumption were associated with higher concentrations of OCPs. Boys who lived < 2 km from the factory complex had 64% (95% CI: 37, 96) and 57% (95% CI: 32, 87) higher mean HCB and β-HCH concentrations, respectively, than boys who lived ≥ 5 km away. Living > 3 years in Chapaevsk predicted higher β-HCH concentrations, and having parents who lacked a high school education predicted higher p,p´-DDE concentrations.Among this cohort of prepubertal Russian boys, predictors of serum OCPs included consumption of local dairy products, longer local residence, and residential proximity to the local factory complex.

PubMed ID: 23955839 Exiting the NIEHS site

MeSH Terms: Animals; Body Mass Index; Breast Feeding/statistics & numerical data; Child; Cohort Studies; Dichlorodiphenyl Dichloroethylene; Diet/statistics & numerical data; Educational Status; Environmental Exposure/analysis*; Geography; Hexachlorobenzene; Humans; Hydrocarbons, Chlorinated/blood*; Lindane; Linear Models; Male; Milk/statistics & numerical data; Pesticides/blood*; Prospective Studies; Russia/epidemiology; Surveys and Questionnaires

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