Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Organs-on-chips at the frontiers of drug discovery.

Authors: Esch, Eric W; Bahinski, Anthony; Huh, Dongeun

Published In Nat Rev Drug Discov, (2015 Apr)

Abstract: Improving the effectiveness of preclinical predictions of human drug responses is critical to reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication and microfluidics have enabled the development of microengineered models of the functional units of human organs - known as organs-on-chips - that could provide the basis for preclinical assays with greater predictive power. Here, we examine the new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening. We also discuss emerging drug discovery opportunities enabled by organs-on-chips, as well as important challenges in realizing the full potential of this technology.

PubMed ID: 25792263 Exiting the NIEHS site

MeSH Terms: Animals; Computer Simulation*; Drug Discovery/methods*; Drug Discovery/trends*; Drug Evaluation, Preclinical; Drug Industry/trends; High-Throughput Screening Assays; Humans; Models, Biological; Pharmacokinetics; Rare Diseases

to Top