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Publication Detail

Title: Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer.

Authors: Singhal, Sunil; Bhojnagarwala, Pratik S; O'Brien, Shaun; Moon, Edmund K; Garfall, Alfred L; Rao, Abhishek S; Quatromoni, Jon G; Stephen, Tom Li; Litzky, Leslie; Deshpande, Charuhas; Feldman, Michael D; Hancock, Wayne W; Conejo-Garcia, Jose R; Albelda, Steven M; Eruslanov, Evgeniy B

Published In Cancer Cell, (2016 Jul 11)

Abstract: Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APCs) in early-stage human lung cancer. These APC-like "hybrid neutrophils," which originate from CD11b(+)CD15(hi)CD10(-)CD16(low) immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. Interferon-γ and granulocyte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.

PubMed ID: 27374224 Exiting the NIEHS site

MeSH Terms: Antigen-Presenting Cells/immunology*; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor/immunology; Humans; Ikaros Transcription Factor/metabolism; Interferon-gamma/immunology; Lung Neoplasms/immunology*; Neoplasm Staging; Neutrophils/cytology; Neutrophils/immunology*; T-Lymphocytes, Cytotoxic/immunology

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