Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Identification of a novel progenitor cell marker, grainyhead-like 2 in the developing pituitary.

Authors: Edwards, Whitney; Nantie, Leah B; Raetzman, Lori T

Published In Dev Dyn, (2016 Nov)

Abstract: Pituitary stem/progenitor cells give rise to all of the endocrine cell types within the pituitary gland and are necessary for both development and gland homeostasis. Recent studies have identified several key factors that characterize the progenitor cell population. However, little is known about the factors that regulate progenitor cell differentiation and maintenance. Therefore, it is crucial to identify novel factors that help elucidate mechanisms of progenitor cell function in the developing pituitary. Our studies are the first to characterize the expression of Grainyhead-like 2 (GRHL2), a transcription factor known to regulate progenitor cell plasticity, in the developing pituitary.Our studies show GRHL2 expression is highest in the embryonic and early postnatal pituitary and is localized in pituitary progenitor cells. We demonstrate GRHL2 expression is changed in Notch2 cKO and Prop1df/df mice, mouse models that display progenitor cell number defects. In addition, our studies indicate a potential relationship between Notch signaling and GRHL2 expression in the developing pituitary.Taken together, our results indicate GRHL2 as a novel progenitor cell maker in the developing pituitary that may contribute to progenitor cell function and maintenance. Developmental Dynamics 245:1097-1106, 2016. © 2016 Wiley Periodicals, Inc.

PubMed ID: 27564454 Exiting the NIEHS site

MeSH Terms: Animals; Gene Expression Regulation, Developmental/genetics; Gene Expression Regulation, Developmental/physiology; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Immunohistochemistry; Mice; Mice, Knockout; Pituitary Gland/embryology; Pituitary Gland/metabolism*; Receptor, Notch2/genetics; Receptor, Notch2/metabolism; Stem Cells/cytology; Stem Cells/metabolism*; Transcription Factors/metabolism*

Back
to Top