Skip Navigation

Publication Detail

Title: Trimester-Specific Urinary Bisphenol A Concentrations and Blood Glucose Levels Among Pregnant Women From a Fertility Clinic.

Authors: Chiu, Yu-Han; Mínguez-Alarcón, Lidia; Ford, Jennifer B; Keller, Myra; Seely, Ellen W; Messerlian, Carmen; Petrozza, John; Williams, Paige L; Ye, Xiaoyun; Calafat, Antonia M; Hauser, Russ; James-Todd, Tamarra; for EARTH Study Team

Published In J Clin Endocrinol Metab, (2017 Apr 01)

Abstract: Women with a history of infertility are at increased risk of impaired glucose tolerance during pregnancy. Studies suggest higher urinary bisphenol A (BPA) concentrations are associated with diabetes in nonpregnant populations, but the association between BPA and glucose levels among pregnant women is unclear.To assess trimester-specific urinary BPA concentrations in relation to blood glucose levels among subfertile women.Environment and Reproductive Health Study, an ongoing prospective cohort study.A fertility center in a teaching hospital.A total of 245 women contributed at least one urine sample during first and/or second trimesters, delivered a singleton or twin pregnancy, and had available blood glucose data (2005 to 2015).Blood glucose levels after a nonfasting 50-g glucose challenge test at 24 to 28 weeks of gestation.The specific gravity-adjusted geometric mean urinary BPA concentrations during first and second trimesters were 1.39 and 1.27 µg/L, respectively. Second-trimester BPA concentrations were positively associated with blood glucose (P, trend = 0.01). Specifically, the adjusted mean glucose levels (95% confidence interval) for women in the highest quartile of second-trimester BPA concentrations was 119 (112, 126) mg/dL compared with 106 (100, 112) mg/dL for women in the lowest quartile. No associations were observed between first-trimester BPA concentrations and glucose levels.BPA exposure during the second trimester may have adverse effect on blood glucose levels among subfertile women. As the findings represent the first report suggesting a potential etiologically relevant window for BPA and glucose in humans, further studies are needed.

PubMed ID: 28323984 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Ambulatory Care Facilities; Benzhydryl Compounds/urine*; Blood Glucose/analysis*; Cohort Studies; Environmental Monitoring/methods; Female; Fertilization in Vitro; Humans; Infertility/blood*; Infertility/therapy; Infertility/urine*; Middle Aged; Phenols/urine*; Pregnancy; Pregnancy Trimesters/blood*; Pregnancy Trimesters/urine*; Reproductive Health; Young Adult

Back
to Top