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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Identifying Vulnerable Periods of Neurotoxicity to Triclosan Exposure in Children.

Authors: Jackson-Browne, Medina S; Papandonatos, George D; Chen, Aimin; Calafat, Antonia M; Yolton, Kimberly; Lanphear, Bruce P; Braun, Joseph M

Published In Environ Health Perspect, (2018 May 02)

Abstract: Exposure to triclosan, an endocrine disrupting chemical, may affect thyroid hormone homeostasis and adversely affect neurodevelopment.Using a longitudinal pregnancy and birth cohort, we investigated associations between triclosan exposures during different time windows, and cognitive test scores at 8 y of age in 198 children from the HOME Study.We quantified triclosan in urine samples from mother-child pairs up to nine times between the second trimester of gestation and 8 y of age. The Wechsler Intelligence Scale for Children-IV [i.e., Full-Scale Intelligence Quotient (IQ)] assessment was administered to HOME Study children at 8 y of age. We estimated covariate-adjusted triclosan-IQ associations at each visit. We also tested whether associations between triclosan concentrations and cognitive test scores varied among exposure at different time periods.Full-Scale IQ was not significantly associated with urinary triclosan concentrations during gestation or childhood but was significantly associated with a 10-fold increase in maternal urinary triclosan concentration at delivery [-4.5 points (95% CI: -7.0, -2.0)]. Perceptual Reasoning Index (PRI) scores were significantly decreased in association with urinary triclosan concentrations at delivery and at 2 y of age. Associations between repeated triclosan concentrations and cognitive test scores significantly varied among exposure at different time periods for Full-Scale IQ, PRI, Verbal Comprehension Index, and Working Memory (triclosan-visit interaction p≤0.04).Urinary triclosan concentrations at delivery, but not during mid to late pregnancy and childhood, were associated with significantly lower children's cognitive test scores at 8 y of age in this cohort of U.S. children. https://doi.org/10.1289/EHP2777.

PubMed ID: 29727133 Exiting the NIEHS site

MeSH Terms: Child; Child Development; Child, Preschool; Cognition/drug effects; Female; Humans; Infant; Infant, Newborn; Intelligence/drug effects; Male; Neurotoxicity Syndromes/diagnosis; Pregnancy; Prenatal Exposure Delayed Effects; Triclosan/toxicity*; Triclosan/urine*

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Last Reviewed: October 02, 2024