Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: PARPi focus the spotlight on replication fork protection in cancer.

Authors: Schlacher, Katharina

Published In Nat Cell Biol, (2017 Oct 31)

Abstract: PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.

PubMed ID: 29087384 Exiting the NIEHS site

MeSH Terms: BRCA1 Protein/genetics; BRCA2 Protein/genetics; DNA Damage/drug effects; DNA Damage/genetics; DNA Repair/drug effects; DNA Repair/genetics; DNA Replication/drug effects*; DNA Replication/genetics; Down-Regulation/drug effects; Down-Regulation/genetics; Enhancer of Zeste Homolog 2 Protein/genetics; Humans; Neoplasms/drug therapy*; Neoplasms/genetics*; Neoplasms/metabolism; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology*; Poly(ADP-ribose) Polymerases/metabolism*

to Top