Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Murine models of accelerated aging and musculoskeletal disease.

Authors: Hambright, William S; Niedernhofer, Laura J; Huard, Johnny; Robbins, Paul D

Published In Bone, (2019 08)

Abstract: The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the potential to slow or prevent multiple age-related musculoskeletal conditions simultaneously. However, the development of approaches to delay onset of age related diseases, including musculoskeletal pathologies, has been slowed by the relatively long lifespan of rodent models of aging. Thus, to expedite the development of therapeutic approaches for age-related musculoskeletal disease, the implementation of mouse models of accelerated musculoskeletal aging are of great utility. Currently there are multiple genetically diverse mouse models that mirror certain aspects of normal human and mouse aging. Here, we provide a review of some of the most relevant murine models of accelerated aging that mimic many aspects of natural musculoskeletal aging, highlighting their relative strengths and weaknesses. Importantly, these murine models of accelerated aging recapitulate phenotypes of musculoskeletal age-related decline observed in humans.

PubMed ID: 30844492 Exiting the NIEHS site

MeSH Terms: Aging/physiology*; Animals; Disease Models, Animal; Humans; Mice; Musculoskeletal Diseases/pathology*; Musculoskeletal Diseases/physiopathology*; Osteoarthritis/pathology; Osteoarthritis/physiopathology; Osteoporosis/pathology; Osteoporosis/physiopathology; Progeria/pathology*; Progeria/physiopathology*

Back
to Top