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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Characterization of Arsenic-Induced Cancer Stem-Like Cells.

Authors: Chang, Qingshan; Bi, Zhuoyue; Fu, Yao; Rice, M' Kya Anique; Zhang, Qian; Wadgaonkar, Priya; Almutairy, Bandar; Zhang, Wenxian; Lu, Yongju; Xu, Liping; Thukar, Chitra; Chen, Fei

Published In Methods Mol Biol, (2020)

Abstract: Arsenic is a well-known human carcinogen. However, the mechanisms underlying arsenic-induced carcinogenesis remain elusive. Here we show that chronic and low level of arsenic stress induces transformation of the human bronchial epithelial cells, BEAS-2B, and that some of the transformed cells show characteristics of cancer stem-like cells (CSCs). Meanwhile, we demonstrate that arsenic stress dedifferentiates CD61+ BEAS-2B cells into CSC-like CD61- cells featured with noncanonical epithelial-mesenchymal transition (EMT), enhanced chemoresistance, and metastasis. Finally, we show that oncogene c-Myc expression is associated with arsenic-induced tumor initiation and progression. Altogether, our findings highlight a unique mechanism of arsenic-induced transformation of human bronchial epithelial cells and provide a novel therapeutic target for arsenic-initiated lung cancer.

PubMed ID: 31960388 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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