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Publication Detail

Title: JARID1a Ablation in the Liver Alters Systemic Metabolism and Adaptation to Feeding.

Authors: DiTacchio, Kacee Ann; Kalinowska, Diana; Saran, Anand Rajamani; Byrne, Ashley; Vollmers, Christopher; DiTacchio, Luciano

Published In Cell Rep, (2020 05 26)

Abstract: The liver is a key regulator of systemic energy homeostasis whose proper function is dependent on the circadian clock. Here, we show that livers deficient in the oscillator component JARID1a exhibit a dysregulation of genes involved in energy metabolism. Importantly, we find that mice that lack hepatic JARID1a have decreased lean body mass, decreased respiratory exchange ratios, faster production of ketones, and increased glucose production in response to fasting. Finally, we find that JARID1a loss compromises the response of the hepatic transcriptome to nutrient availability. In all, ablation of hepatic JARID1a disrupts the coordination of hepatic metabolic programs with whole-body consequences.

PubMed ID: 32460011 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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