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Title: Effects of particulate matter gamma radiation on oxidative stress biomarkers in COPD patients.

Authors: Huang, Shaodan; Koutrakis, Petros; Grady, Stephanie T; Vieira, Carolina L Z; Schwartz, Joel D; Coull, Brent A; Hart, Jaime E; Laden, Francine; Zhang, Junfeng Jim; Garshick, Eric

Published In J Expo Sci Environ Epidemiol, (2021 Jul)

Abstract: Inhalation of particulate matter (PM) radioactivity is an important pathway of ionizing radiation exposure. We investigated the associations between short-term exposures to PM gamma radioactivity with oxidative stress in COPD patients. Urinary concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) of 81 COPD patients from Eastern Massachusetts were measured 1-4 times during 2012-2014. Daily ambient and indoor PM gamma activities (gamma-3 through gamma-9) were calculated based on EPA RadNet data and indoor-outdoor infiltration ratios. Linear mixed-effects models were used to examine the associations between biomarkers with PM gamma activities for moving averages from urine collection day to 7 days before. Our results indicate that ambient and indoor PM gamma activities were positively associated with 8-OHdG, with stronger effects for exposure windows closer to urine collection day. For per interquartile range increase in indoor PM gamma activities averaged over urine collection day and 1 day before, 8-OHdG increased from 3.41% (95% CI: -0.88, 7.88) to 8.87% (95% CI: 2.98, 15.1), adjusted for indoor black carbon. For MDA, the timing of greatest effects across the exposure week varied but was nearly all positive. These findings provide insight into the toxigenic properties associated with PM radioactivity and suggest that these exposures promote systemic oxidative stress.

PubMed ID: 32015432 Exiting the NIEHS site

MeSH Terms: Air Pollutants*/adverse effects; Air Pollutants*/analysis; Biomarkers; Gamma Rays; Humans; Massachusetts; Oxidative Stress; Particulate Matter/adverse effects; Particulate Matter/analysis; Pulmonary Disease, Chronic Obstructive*

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