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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Insights into glucocorticoid responses derived from omics studies.

Authors: Kan, Mengyuan; Himes, Blanca E

Published In Pharmacol Ther, (2021 02)

Abstract: Glucocorticoid drugs are commonly used in the treatment of several conditions, including autoimmune diseases, asthma and cancer. Despite their widespread use and knowledge of biological pathways via which they act, much remains to be learned about the cell type-specific mechanisms of glucocorticoid action and the reasons why patients respond differently to them. In recent years, human and in vitro studies have addressed these questions with genomics, transcriptomics and other omics approaches. Here, we summarize key insights derived from omics studies of glucocorticoid response, and we identify existing knowledge gaps related to mechanisms of glucocorticoid action that future studies can address.

PubMed ID: 32910934 Exiting the NIEHS site

MeSH Terms: Genomics; Glucocorticoids*/pharmacology; Humans

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