Title: Determinants of phthalate exposure among a U.S.-based group of Latino workers.
Authors: Allotey, Janice A; Boyle, Meleah; Sapkota, Amir; Zhu, Linyan; Peng, Roger D; Garza, Mary A; Quirós-Alcalá, Lesliam
Published In Int J Hyg Environ Health, (2021 May)
Abstract: BACKGROUND: Phthalates are endocrine disrupting compounds linked to various adverse health effects. U.S. national biomonitoring data indicate that select minority subgroups may suffer disparate exposures to phthalates. Still, exposures and their respective determinants among these subgroups are not well characterized. OBJECTIVE: We sought to examine determinants of phthalate exposure in a subsample of US-based Latino adults. METHODS: We conducted a cross-sectional study on 94 Latino immigrant adults in Maryland. Participants were >18 years of age and working in a service-based industry. We administered an interviewer-administered questionnaire to capture information on potential exposure determinants (e.g., demographic characteristics, consumer product use, and workplace exposures and behaviors) and using HPLC/MS-MS we quantified concentrations of 9 urinary phthalate metabolites: monoethyl phthalate (MEP, diethyl phthalate metabolite); mono-n-butyl phthalate (MBP, di-n-butyl phthalate metabolite); mono-isobutyl phthalate (MiBP, di-isobutyl phthalate metabolite; monobenzyl phthalate (MBzP, benzylbutyl phthalate metabolite); molar sum of di-2-ethylhexyl phthalate or DEHP metabolites [mono-2-ethylhexyl phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-(2-ethyl-5-carboxypentyl) phthalate (MECCP)]; and mono(3-carboxypropyl) phthalate (MCPP, a non-specific metabolite of several phthalates including di-n-butyl phthalate and di-n-octyl phthalate). DEHP was analyzed as the molar sum of four metabolites (ΣDEHP = MEHP + MEHHP + MECPP + MEOHP). Spearman correlations, Wilcoxon-Mann-Whitney, and Kruskal-Wallis tests were conducted to assess bivariate associations between metabolite concentrations and potential exposure determinants. Covariates associated with metabolites at p < 0.10 in bivariate analyses were included in multivariable linear regression models to assess the independent effects of predictors on metabolite concentrations. RESULTS: Uncorrected median phthalate metabolite concentrations were lower in our study population (
PubMed ID: 33836349
MeSH Terms: No MeSH terms associated with this publication