Title: Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States.
Authors: Randad, Pranay R; Larsen, Jesper; Kaya, Hülya; Pisanic, Nora; Ordak, Carly; Price, Lance B; Aziz, Maliha; Nadimpalli, Maya L; Rhodes, Sarah; Stewart, Jill R; Love, Dave C; Mohr, David; Davis, Meghan F; Miller, Lloyd S; Hall, Devon; Carroll, Karen C; Perl, Trish M; Heaney, Christopher D
Published In Emerg Infect Dis, (2021 03)
Abstract: Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0-34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.
PubMed ID: 33622471
MeSH Terms: No MeSH terms associated with this publication