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Title: Association of immune cell subsets with cardiac mechanics in the Multi-Ethnic Study of Atherosclerosis.

Authors: Sinha, Arjun; Rivera, Adovich S; Doyle, Margaret F; Sitlani, Colleen; Fohner, Alison; Huber, Sally A; Olson, Nels C; Lima, Joao Ac; Delaney, Joseph A; Feinstein, Matthew J; Shah, Sanjiv J; Tracy, Russel P; Psaty, Bruce M

Published In JCI Insight, (2021 07 08)

Abstract: BackgroundImmunomodulatory therapy may help prevent heart failure (HF). Data on immune cells and myocardial remodeling in older adults with cardiovascular risk factors are limited.MethodsIn the Multi-Ethnic Study of Atherosclerosis cohort, 869 adults had 19 peripheral immune cell subsets measured and underwent cardiac MRI during the baseline exam, of which 321 had assessment of left ventricular global circumferential strain (LV-GCS). We used linear regression with adjustment for demographics, cardiovascular risk factors, and cytomegalovirus serostatus to evaluate the cross-sectional association of immune cell subsets with left ventricular mass index (LVMI) and LV-GCS.ResultsThe average age of the cohort was 61.6 ± 10.0 years and 53% were women. Higher proportions of γ/δ T cells were associated with lower absolute (worse) LV-GCS (-0.105% [95% CI -0.164%, -0.046%] per 1 SD higher proportion of γ/δ T cells, P = 0.0006). This association remained significant after Bonferroni's correction. Higher proportions of classical monocytes were associated with worse absolute LV-GCS (-0.04% [95% CI -0.07%, 0.00%] per 1 SD higher proportion of classical monocytes, P = 0.04). This did not meet significance after Bonferroni's correction. There were no other significant associations with LV-GCS or LVMI.ConclusionPathways associated with γ/δ T cells may be potential targets for immunomodulatory therapy targeted at HF prevention in populations at risk.FundingContracts 75N92020D00001, HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 and grant R01 HL98077 from the National Heart, Lung, and Blood Institute/NIH and grants KL2TR001424, UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences/NIH.

PubMed ID: 34236048 Exiting the NIEHS site

MeSH Terms: Atherosclerosis*/blood; Atherosclerosis*/physiopathology; Cohort Studies; Female; Heart Disease Risk Factors; Heart Failure*/immunology; Heart Failure*/prevention & control; Heart Ventricles*/diagnostic imaging; Heart Ventricles*/pathology; Humans; Immunomodulation; Magnetic Resonance Imaging, Cine/methods; Magnetic Resonance Imaging, Cine/statistics & numerical data; Male; Middle Aged; Monocytes/immunology*; Organ Size; Risk Factors; T-Lymphocyte Subsets/immunology*; Ventricular Dysfunction, Left*/diagnosis; Ventricular Dysfunction, Left*/immunology; Ventricular Remodeling/immunology

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