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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Profiles of primary aromatic amines, nicotine, and cotinine in indoor dust and associated human exposure in China.

Authors: Chinthakindi, Sridhar; Zhu, Qingqing; Liao, Chunyang; Kannan, Kurunthachalam

Published In Sci Total Environ, (2022 Feb 01)

Abstract: Despite the widespread use of primary aromatic amines (AAs) in consumer products, little is known about their prevalence in house dust. In this study, we investigated the occurrence of 35 AAs and two tobacco chemical markers (nicotine and its breakdown product cotinine) in 119 samples of house dust collected from five provinces in China. Ten of the 35 AAs and [nicotine and cotinine] were found in >80% and 100% of the samples, respectively, at concentration ranges of 29.1-19,200 (median: 700 ng/g) and 23.2-22,400 (4600) ng/g, respectively. Aniline was the predominant AA found in all dust samples (median: 257 ng/g). Dust samples from Henan and Shanxi provinces contained higher summed concentrations of the 10 AAs than those from Sichuan and Shandong, although the concentrations did not vary significantly among the five provinces (p > 0.05). A significant (p = 0.048), positive correlation (r = 0.882) existed between concentrations of nicotine and cotinine in dust samples. Similarly, concentrations of AAs were significantly correlated with those of nicotine in dust samples. Dyestuffs, rubber products, polyurethane foam and tobacco smoke are the major sources of AAs in the indoor environment. The estimated daily intakes (EDI) through dust ingestion ranged from 0.349 (adults) to 6.62 ng/kg-bw/day (toddlers) for AAs and from 1.27 to 51.1 ng/kg-bw/day for nicotine which are well below the current tolerable daily intakes.

PubMed ID: 34740640 Exiting the NIEHS site

MeSH Terms: Adult; Air Pollution, Indoor*/analysis; Amines; China; Cotinine*; Dust/analysis; Environmental Exposure/analysis; Humans; Nicotine/analysis

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