Title: VCAM-1 Is Upregulated in Uranium Miners Compared to Other Miners.

Authors: Ass'ad, Nour A; Shore, Xin; Myers, Orrin; Camacho, Alexandra R; Jacquez, Quiteria; Pollard, Charles; Cook, Linda S; Leng, Shuguang; Page, Kimberly; Sood, Akshay; Zychowski, Katherine E

Published In Life (Basel), (2021 Nov 11)

Abstract: The United States has a rich history of mining including uranium (U)-mining, coal mining, and other metal mining. Cardiovascular diseases (CVD) are largely understudied in miners and recent literature suggests that when compared to non-U miners, U-miners are more likely to report CVD. However, the molecular basis for this phenomenon is currently unknown. In this pilot study, a New Mexico (NM)-based occupational cohort of current and former miners (n = 44) were recruited via a mobile screening clinic for miners. Serum- and endothelial-based endpoints were used to assess circulating inflammatory potential relevant to CVD. Non-U miners reported significantly fewer pack years of smoking than U-miners. Circulating biomarkers of interest revealed that U-miners had significantly greater serum amyloid A (SAA), soluble intercellular adhesion molecule 1 (ICAM-1, ng/mL), soluble vascular cell adhesion molecule 1 (VCAM-1, ng/mL), and VCAM-1 mRNA expression, as determined by the serum cumulative inflammatory potential (SCIP) assay, an endothelial-based assay. Even after adjusting for various covariates, including age, multivariable analysis determined that U-miners had significantly upregulated VCAM-1 mRNA. In conclusion, VCAM-1 may be an important biomarker and possible contributor of CVD in U-miners. Further research to explore this mechanism may be warranted.

PubMed ID: 34833099

MeSH Terms: No MeSH terms associated with this publication