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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation.

Authors: Stapleton, Emma M; Welch, Jennifer L; Ubeda, Erika A; Xiang, Jinhua; Zabner, Joseph; Thornell, Ian M; Nonnenmann, Matthew W; Stapleton, Jack T; Comellas, Alejandro P

Published In J Infect Dis, (2022 Jan 18)

Abstract: Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.

PubMed ID: 34734257 Exiting the NIEHS site

MeSH Terms: Antiviral Agents/pharmacology; COVID-19*/prevention & control; COVID-19*/transmission; Coronavirus 229E, Human*; Humans; Immunity, Innate*; Particulate Matter/adverse effects*; Polymerase Chain Reaction; SARS-CoV-2; Urban Health; Urban Population*

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