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Publication Detail

Title: Is developmental synchrony enabled by CTCF residence time?

Authors: Wang, Hsiao-Lin V; Corces, Victor G

Published In Dev Cell, (2021 09 27)

Abstract: Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.

PubMed ID: 34582771 Exiting the NIEHS site

MeSH Terms: CCCTC-Binding Factor; Cell Differentiation; Cell Line; Repressor Proteins*/genetics; Repressor Proteins*/metabolism

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