Title: Is developmental synchrony enabled by CTCF residence time?
Authors: Wang, Hsiao-Lin V; Corces, Victor G
Published In Dev Cell, (2021 09 27)
Abstract: Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.
PubMed ID: 34582771
MeSH Terms: CCCTC-Binding Factor; Cell Differentiation; Cell Line; Repressor Proteins*/genetics; Repressor Proteins*/metabolism