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National Institute of Environmental Health Sciences

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Publication Detail

Title: An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis.

Authors: Pi, Hualiang; Weiss, Andy; Laut, Clare L; Grunenwald, Caroline M; Lin, Hannah K; Yi, Xinjie I; Stauff, Devin L; Skaar, Eric P

Published In Nat Commun, (2022 Mar 21)

Abstract: HitRS is a two-component system that responds to cell envelope damage in the human pathogen Bacillus anthracis. Here we identify an RNA-binding protein, KrrA, that regulates HitRS function by modulating the stability of the hitRS mRNA. In addition to hitRS, KrrA binds to over 70 RNAs and, directly or indirectly, affects the expression of over 150 genes involved in multiple processes, including genetic competence, sporulation, RNA turnover, DNA repair, transport, and cellular metabolism. KrrA does not exhibit detectable nuclease activity in vitro, and thus the mechanism by which it modulates mRNA stability remains unclear.

PubMed ID: 35314695 Exiting the NIEHS site

MeSH Terms: Bacillus anthracis*/genetics; Bacillus anthracis*/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Wall/metabolism; Gene Expression Regulation, Bacterial; Humans; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism

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