Title: A tipping point in cancer epidemiology: embracing a life course exposomic framework.
Authors: Wright, Rosalind J; Hanson, Heidi A
Published In Trends Cancer, (2022 Apr)
Abstract: The pathogenesis of multifactorial malignant diseases, with variable onset, severity, and natural history, reflects development-specific exposures and individual responses to these exposures influenced by underlying genetic predisposition. Embedded in life course theory, exposomics provides a framework to more fully elucidate how environmental factors alter cancer risk, disease course, and response to treatment across the lifespan.
PubMed ID: 35181274
MeSH Terms: Environmental Exposure/adverse effects; Humans; Life Change Events*; Neoplasms*/etiology; Neoplasms*/genetics