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Title: Anti-Müllerian Hormone Levels among Female Firefighters.

Authors: Davidson, Samantha; Jahnke, Sara; Jung, Alesia M; Burgess, Jefferey L; Jacobs, Elizabeth T; Billheimer, Dean; Farland, Leslie V

Published In Int J Environ Res Public Health, (2022 May 14)

Abstract: Female firefighters have occupational exposures which may negatively impact their reproductive health. Anti-müllerian hormone (AMH) is a clinical marker of ovarian reserve. We investigated whether AMH levels differed in female firefighters compared to non-firefighters and whether there was a dose-dependent relationship between years of firefighting and AMH levels. Female firefighters from a pre-existing cohort completed a cross-sectional survey regarding their occupational and health history and were asked to recruit a non-firefighter friend or relative. All participants provided a dried blood spot (DBS) for AMH analysis. Linear regression was used to assess the relationship between firefighting status and AMH levels. Among firefighters, the influence of firefighting-related exposures was evaluated. Firefighters (n = 106) and non-firefighters (n = 58) had similar age and BMI. Firefighters had a lower mean AMH compared to non-firefighters (2.93 ng/mL vs. 4.37 ng/mL). In multivariable adjusted models, firefighters had a 33% lower AMH value than non-firefighters (-33.38%∆ (95% CI: -54.97, -1.43)). Years of firefighting was not associated with a decrease in AMH. Firefighters in this study had lower AMH levels than non-firefighters. More research is needed to understand the mechanisms by which firefighting could reduce AMH and affect fertility.

PubMed ID: 35627519 Exiting the NIEHS site

MeSH Terms: Anti-Mullerian Hormone*/metabolism; Cross-Sectional Studies; Female; Firefighters*; Humans; Occupational Exposure; Ovarian Reserve*; Peptide Hormones

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