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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Final Progress Reports: Boston University: Training Core

Superfund Research Program

Training Core

Project Leader: Michael D. McClean
Co-Investigator: Jean van Seventer (Boston University School of Public Health)
Grant Number: P42ES007381
Funding Period: 2017-2021

Project-Specific Links

Final Progress Reports

Year:   2016  2004 

During the 2004-05 year, Dr. Callard’s research team continued the support of the two Bioinformatics students at the level of 79%, and one Biology student at the 24% stipend level (the remaining stipend was supplied from other PI grants). Silberstein (Bioinformatics), who continues to be mentored by John Stegeman and Sandor Vajda, is making progress toward homology modeling of the cytochrome P450 monoxygenases with the goal of elucidating active site variability. Clodfelter (Bioinformatics) continues to be mentored by David Waxman and Sandor Vajda in the area of homology modeling and docking as applied to P450 monoxygenases. Wood (Biology) is being mentored by Gloria Callard with advice from the Bioinformatics Core. She is progressing on her studies of phylogenetic analysis as a tool for understanding species variations in the interaction of xenoestrogens with the estrogen receptor.

These students represent a significant contribution to the pool of students with cross-disciplinary training in biology and bioinformatics, with a focus on environmental contaminants and their interactions with ligands at the molecular level. Silberstein and Clodfelter have participated in the national meetings of the American Chemical Society and report publications in collaboration with their PIs.

With regard to curriculum, Weng continues to teach the core course (Protein and DNA Sequence Analysis) in the Bioinformatics program, which students are required to take, and to provide advice to trainees on research related to protein-ligand interactions. Ian Callard teaches the basic course in reproductive and developmental physiology and biochemistry for biology students and is responsible for the interface between the Superfund Training Core and the NICHD Training Program in Reproductive Endocrinology, now in its eleventh year.

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