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Your Environment. Your Health.

Progress Reports: Michigan State University: Research Translation Core

Superfund Research Program

Research Translation Core

Project Leader: Brad L. Upham
Grant Number: P42ES004911
Funding Period: 2006-2020
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page

Progress Reports

Year:   2019  2018  2017  2016  2015  2014  2013  2012  2011  2010  2009  2008  2007  2006 

Three specific goals were proposed in the original proposal:

  1. Development of WEB site [Molecular Biology Tools Repository (MBTR) for bioremediation workers, researchers and policy makers to be created for the enhancement of the quality and efficiency of risk assessment purposes].
  2. Annual seminars and natural meetings to help facilitate internal and external research collaborations and educational outreach of the research.
  3. An international meeting to highlight the progress made on the total research projects.
Advances Made in 2007:
  1. Progress towards partnering with governmental agencies. While the initial efforts of the aims of this core did not include the direct partnering with government agencies until both the WEB tool was starting to be developed, this core made indirect efforts to involve both Michigan and Midwest Regional agencies in the seminar series and in the first annual meeting {see 3 below}
  2. Progress towards conducting technology transfer. The Research Translation core is developing a Molecular Biology Tool Kit (MBTK) based on software tools developed by the Center’s research in detection of biodegradative activity in the environment. The Core researchers have enhanced the Functional Gene Pipeline/Repository component of the MBTK. These enhancements include adding additional video tutorials and extensive modifications to the phylogenetic tree-building component. In addition, they are expanding their toolkit to provide specialized tools for new sequencing technologies, such as 454 pyrosequencing that generate tens to hundreds of thousand of sequences at the time. Dr. Trosko and his team developed tools to align, cluster, dereplicate and simplify the computing-intensive analysis. The toolkit also provides output files compatible with specialized statistical analysis packages, such as R, EstimateS, and SPADE.
  3. Progress toward communicating to broad audiences, including pages and print materials development. The Research Translation Core held its first annual meeting on September 19th at the Kellogg Center, Michigan State University on “The NAS and WHO on Dioxin and Dioxin-Like Compounds: International Policy Implications and Potential Impact,” with 105 participants representing governmental agents (22), foundations/consulting firms (27), and academia (56). In addition, the Research Translation Core held several seminars to which MSU Program project investigators, MSU-wide faculty, Michigan government agencies, and private industry were invited and attended. [Stephen Safe, “ Selective AhR modulators: Opportunities for cancer chemotherapy and problems for risk assessment”, July 10, 2007].
  4. Preparation of attendance to the Superfund SBRP annual meeting for poster presentation [E. Cardenas, J.R. Cole, A.S. Kulam-Syed-Mohideen, Q. Wang, B. Chai, B. Upham, S. Hashsham, J. Trosko, and N.E. Kaminski. ”The MSU SBRP Molecular Biology Tools Repository.” NIEHS SBRP Superfund Symposium, Research Triangle Park, N.C., November, 2007.]

    Significance of Progress

    The Functional Gene Pipeline/Repository component of the Molecular Biology Tool Kit is now used by researchers from both the US and Europe. On average, it receives over 5000 visits from over 700 unique IP addresses each month. The Annual Meeting helped disseminate up-to-date information on dioxin policy implications to government, academia, and industry.

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