Superfund Research Program
A Holistochastic Approach to Human Exposure Assessment
Project Leader: George Christakos
Grant Number: P42ES005948
Funding Period: 1995 - 2006
Project researchers successfully developed conceptual and mathematical tools for the rigorous modeling of environmental fate and exposure processes. A major achievement is the development of novel and advanced methods (diagrammatic, space transformation and differential geometric methods) that incorporate various sources of physical knowledge into the quantitative analysis of environmental fate and exposure processes occurring at a variety of space/time scales. These powerful methods advance understanding of environmental fate and can be used to analyze the effects of natural variability, scale and uncertainty. They lead to more accurate predictions of spatiotemporal environmental processes and pollutant exposures than commonly used perturbation methods. The methods permit transfer of information across scales by means of rigorous mathematical transformations, and they produce estimates that incorporate measures of uncertainty, which can be used for improved exposure assessment. These methods may also lead to identification of explicit relations between concentrations of pollutants, human exposure, and measures of health risk.