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Progress Reports: Dartmouth College: Arsenic as an Endocrine Disrupter

Superfund Research Program

Arsenic as an Endocrine Disrupter

Project Leaders: Joshua W. Hamilton (Marine Biological Laboratory), Joshua W. Hamilton (Marine Biological Laboratory)
Grant Number: P42ES007373
Funding Period: 1995-2014

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Progress Reports

Year:   2013  2012  2011  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000  1999  1998  1997  1996  1995 

The hypothesis under study is as follows: the genotoxic and carcinogenic metals, chromium and nickel, preferentially interact with the DNA of inducible genes, leading to alterations in their regulation, whereas the non-genotoxic and carcinogenic metals, arsenic and cadmium, principally interact with transcription factors and other signaling proteins also leading to specific alterations in gene expression. To date, it has been demonstrated that both chromium and arsenic alter expression of the model inducible gene, phosphenolpyruvate carboxykinase (PEPCK), but through different mechanisms, and that this occurs at non-overtly toxic doses both in whole animals in vivo and in cells in culture. The design and synthesis of a genetic construct consisting of the PEPCK promoter DNA region linked to a reporter gene has been completed, so that these issues can be examined in more detail at the molecular level. Finally, different cell lines with specific deletions in either their PEPCK DNA or deficiencies in specific transcription factors that regulate the PEPCK gene are being generated, so that the most important targets for these heavy metal effects can be determined.

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